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The last 5 uploaded publications
The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction
Daniel C. Rowe, Anne F. McGettrick, Eicke Latz, Brian G. Monks, Nicholas J. Gay, Masahiro Yamamoto, Akira Shizuo, Luke O'neill, Katherine A. Fitzgerald, Douglas T. Golenbock (2006). The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction. Proceedings of the National Academy of Sciences, 103(16), pp. 6299-6304, DOI: 10.1073/pnas.0510041103.
Article173 days agoSuccinate is an inflammatory signal that induces IL-1β through HIF-1α
Gillian M. Tannahill, Annie M. Curtis, Juraj Adamik, Eva M. Pålsson‐McDermott, Anne F. McGettrick, Gautam Goel, Christian Frezza, Nicholas J. Bernard, Beth Kelly, Niamh H. Foley, Liang Zheng, Agnès Gardet, Zhen Tong, S. S. Jany, Sinéad C. Corr, Moritz Haneklaus, Brian E. Caffrey, Kerry A. Pierce, Sarah R. Walmsley, Federico C. Beasley, Eoin P. Cummins, Victor Nizet, Moira K. B. Whyte, Cormac T. Taylor, Hening Lin, Seth L. Masters, Eyal Gottlieb, Vincent P. Kelly, Clary B. Clish, Philip E. Auron, Ramnik J. Xavier, Luke O'neill (2013). Succinate is an inflammatory signal that induces IL-1β through HIF-1α. Nature, 496(7444), pp. 238-242, DOI: 10.1038/nature11986.
Article167 days agoItaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1
Evanna L. Mills, Dylan G. Ryan, Hiran A. Prag, Dina Dikovskaya, Deepthi Menon, Zbigniew Zasłona, Mark P. Jedrychowski, Ana S.H. Costa, Maureen Higgins, Emily Hams, John Szpyt, Marah C. Runtsch, Martin S. King, Joanna F. McGouran, Román Fischer, Benedikt M. Kessler, Anne F. McGettrick, Mark Hughes, Richard G. Carroll, Lee M. Booty, Elena V. Knatko, Paul J. Meakin, Michael L.J. Ashford, Louise K. Modis, Gino Brunori, Daniel C. Sévin, Padraic G. Fallon, Stuart T. Caldwell, Edmund R.S. Kunji, Edward T. Chouchani, Christian Frezza, Albena T. Dinkova‐Kostova, Richard C. Hartley, Michael P. Murphy, Luke O'neill (2018). Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1. Nature, 556(7699), pp. 113-117, DOI: 10.1038/nature25986.
Article167 days agoThe Role of HIF in Immunity and Inflammation
Anne F. McGettrick, Luke O'neill (2020). The Role of HIF in Immunity and Inflammation. Cell Metabolism, 32(4), pp. 524-536, DOI: 10.1016/j.cmet.2020.08.002.
Article167 days agoThe Immunomodulatory Metabolite Itaconate Modifies NLRP3 and Inhibits Inflammasome Activation
Alexander Hooftman, Stefano Angiari, Svenja Hester, Sarah E. Corcoran, Marah C. Runtsch, Chris Ling, Melanie C. Ruzek, Peter F. Slivka, Anne F. McGettrick, Kathy Banahan, Mark Hughes, Alan D. Irvine, Román Fischer, Luke O'neill (2020). The Immunomodulatory Metabolite Itaconate Modifies NLRP3 and Inhibits Inflammasome Activation. Cell Metabolism, 32(3), pp. 468-478.e7, DOI: 10.1016/j.cmet.2020.07.016.
Article167 days ago