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Get Free AccessHIF is a transcription factor that plays an essential role in the cellular response to low oxygen, orchestrating a metabolic switch that allows cells to survive in this environment. In immunity, infected and inflamed tissues are often hypoxic, and HIF helps immune cells adapt. HIF-α stabilization can also occur under normoxia during immunity and inflammation, where it regulates metabolism but in addition can directly regulate expression of immune genes. Here we review the role of HIF in immunity, including its role in macrophages, dendritic cells, neutrophils, T cells, and B cells. Its role in immunity is as essential for cellular responses as it is in its original role in hypoxia, with HIF being implicated in multiple inflammatory diseases and in immunosuppression in tumors.
Anne F. McGettrick, Luke O'neill (2020). The Role of HIF in Immunity and Inflammation. Cell Metabolism, 32(4), pp. 524-536, DOI: 10.1016/j.cmet.2020.08.002.
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Type
Article
Year
2020
Authors
2
Datasets
0
Total Files
0
Language
English
Journal
Cell Metabolism
DOI
10.1016/j.cmet.2020.08.002
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