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The last 5 uploaded publications
Impaired Basophil Induction Leads to an Age-Dependent Innate Defect in Type 2 Immunity during Helminth Infection in Mice
Hendrik J. Nel, Emily Hams, Sean P. Saunders, Niamh E. Mangan, Philip Smith, Ann Atzberger, Richard A. Flavell, Akira Shizuo, Andrew N. J. McKenzie, Padraic G. Fallon (2011). Impaired Basophil Induction Leads to an Age-Dependent Innate Defect in Type 2 Immunity during Helminth Infection in Mice. The Journal of Immunology, 186(8), pp. 4631-4639, DOI: 10.4049/jimmunol.1002995.
Article168 days agoItaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1
Evanna L. Mills, Dylan G. Ryan, Hiran A. Prag, Dina Dikovskaya, Deepthi Menon, Zbigniew Zasłona, Mark P. Jedrychowski, Ana S.H. Costa, Maureen Higgins, Emily Hams, John Szpyt, Marah C. Runtsch, Martin S. King, Joanna F. McGouran, Román Fischer, Benedikt M. Kessler, Anne F. McGettrick, Mark Hughes, Richard G. Carroll, Lee M. Booty, Elena V. Knatko, Paul J. Meakin, Michael L.J. Ashford, Louise K. Modis, Gino Brunori, Daniel C. Sévin, Padraic G. Fallon, Stuart T. Caldwell, Edmund R.S. Kunji, Edward T. Chouchani, Christian Frezza, Albena T. Dinkova‐Kostova, Richard C. Hartley, Michael P. Murphy, Luke O'neill (2018). Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1. Nature, 556(7699), pp. 113-117, DOI: 10.1038/nature25986.
Article168 days agoItaconate and itaconate derivatives target JAK1 to suppress alternative activation of macrophages
Marah C. Runtsch, Stefano Angiari, Alexander Hooftman, Ridhima Wadhwa, Yanling Zhang, Yunan Zheng, Joseph S. Spina, Melanie C. Ruzek, M.A. Argiriadi, Anne F. McGettrick, Rui Santalla Méndez, Alessia Zotta, Christian G. Peace, Aoife Walsh, Roberta Chirillo, Emily Hams, Padraic G. Fallon, Ranjith Jayaraman, Kamal Dua, Alexandra C. Brown, Richard Kim, Jay C. Horvat, Philip M. Hansbro, Chu Wang, Luke O'neill (2022). Itaconate and itaconate derivatives target JAK1 to suppress alternative activation of macrophages. Cell Metabolism, 34(3), pp. 487-501.e8, DOI: 10.1016/j.cmet.2022.02.002.
Article168 days agoRole for Retinoic Acid-Related Orphan Receptor Alpha (RORα) Expressing Macrophages in Diet-Induced Obesity
Emily Hams, Joseph Roberts, Rachel Bermingham, Andrew E. Hogan, Donal O’Shea, Luke O'neill, Padraic G. Fallon (2020). Role for Retinoic Acid-Related Orphan Receptor Alpha (RORα) Expressing Macrophages in Diet-Induced Obesity. Frontiers in Immunology, 11, DOI: 10.3389/fimmu.2020.01966.
Article168 days ago