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The last 5 uploaded publications
Reprogrammed <scp>mRNA</scp> translation drives resistance to therapeutic targeting of ribosome biogenesis
Eric Kusnadi, Anna Trigos, Carleen Cullinane, David L. Goode, Ola Larsson, Jennifer R. Devlin, Keefe T. Chan, David P. De Souza, Malcolm J. McConville, Grant A. McArthur, George Thomas, Elaine Sanij, Gretchen Poortinga, Ross D. Hannan, Katherine M. Hannan, Jian Kang, Richard B. Pearson (2020). Reprogrammed <scp>mRNA</scp> translation drives resistance to therapeutic targeting of ribosome biogenesis. , 39(21), DOI: https://doi.org/10.15252/embj.2020105111.
Article62 days agoCystathionine-β-synthase is essential for AKT-induced senescence and suppresses the development of gastric cancers with PI3K/AKT activation
Haoran Zhu, Keefe T. Chan, Xinran Huang, Carmelo Cerra, Shaun Blake, Anna Trigos, Dovile Anderson, Darren J. Creek, David P. De Souza, Xi Wang, Caiyun Fu, Metta Jana, Elaine Sanij, Richard B. Pearson, Jian Kang (2022). Cystathionine-β-synthase is essential for AKT-induced senescence and suppresses the development of gastric cancers with PI3K/AKT activation. , 11, DOI: https://doi.org/10.7554/elife.71929.
Article62 days agoAuthor response: Cystathionine-β-synthase is essential for AKT-induced senescence and suppresses the development of gastric cancers with PI3K/AKT activation
Haoran Zhu, Keefe T. Chan, Xinran Huang, Carmelo Cerra, Shaun Blake, Anna Trigos, Dovile Anderson, Darren J. Creek, David P. De Souza, Xi Wang, Caiyun Fu, Metta Jana, Elaine Sanij, Richard B. Pearson, Jian Kang (2022). Author response: Cystathionine-β-synthase is essential for AKT-induced senescence and suppresses the development of gastric cancers with PI3K/AKT activation. , DOI: https://doi.org/10.7554/elife.71929.sa2.
Preprint62 days agoCystathionine-β-synthase is essential for AKT-induced senescence and suppresses the development of gastric cancers with PI3K/AKT activation
Haoran Zhu, Keefe T. Chan, Xinran Huang, Shaun Blake, Anna Trigos, Dovile Anderson, Darren J. Creek, David P. De Souza, Xi Wang, Caiyun Fu, Metta Jana, Elaine Sanij, Richard B. Pearson, Jian Kang (2021). Cystathionine-β-synthase is essential for AKT-induced senescence and suppresses the development of gastric cancers with PI3K/AKT activation. , DOI: https://doi.org/10.1101/2021.07.04.451041.
Preprint62 days agoCX-5461 activates the DNA damage response and demonstrates therapeutic efficacy in high-grade serous ovarian cancer
Elaine Sanij, Katherine M. Hannan, Jiachen Xuan, Shunfei Yan, Jessica E. Ahern, Anna Trigos, Natalie Brajanovski, Jinbae Son, Keefe T. Chan, Olga Kondrashova, Elizabeth Lieschke, Matthew J. Wakefield, Daniel Frank, Sarah Ellis, Carleen Cullinane, Jian Kang, Gretchen Poortinga, Purba Nag, Andrew J. Deans, Kum Kum Khanna, Linda Mileshkin, Grant A. McArthur, John Soong, Els M.J.J. Berns, Ross D. Hannan, Clare L. Scott, Karen E. Sheppard, Richard B. Pearson (2020). CX-5461 activates the DNA damage response and demonstrates therapeutic efficacy in high-grade serous ovarian cancer. , 11(1), DOI: https://doi.org/10.1038/s41467-020-16393-4.
Article62 days ago