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Get Free AccessHyperactivation of oncogenic pathways downstream of RAS and PI3K/AKT in normal cells induces a senescence-like phenotype that acts as a tumor-suppressive mechanism that must be overcome during transformation. We previously demonstrated that AKT-induced senescence (AIS) is associated with profound transcriptional and metabolic changes. Here, we demonstrate that human fibroblasts undergoing AIS display upregulated cystathionine-β-synthase (CBS) expression and enhanced uptake of exogenous cysteine, which lead to increased hydrogen sulfide (H
Haoran Zhu, Keefe T. Chan, Xinran Huang, Carmelo Cerra, Shaun Blake, Anna Trigos, Dovile Anderson, Darren J. Creek, David P. De Souza, Xi Wang, Caiyun Fu, Metta Jana, Elaine Sanij, Richard B. Pearson, Jian Kang (2022). Cystathionine-β-synthase is essential for AKT-induced senescence and suppresses the development of gastric cancers with PI3K/AKT activation. , 11, DOI: https://doi.org/10.7554/elife.71929.
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Type
Article
Year
2022
Authors
15
Datasets
0
Total Files
0
Language
en
DOI
https://doi.org/10.7554/elife.71929
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