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Autophagy is required for the therapeutic effects of the NAD+ precursor nicotinamide in obesity-related heart failure with preserved ejection fraction
Mahmoud Abdellatif, Francisco Vasques‐Nóvoa, Viktoria Trummer-Herbst, Sylvère Durand, Franziska Koser, Moydul Islam, Jihoon Nah, Eun‐Ah Sung, Ruli Feng, Fanny Aprahamian, Andreas Prokesch, Andreas Prokesch, Junichi Sadoshima, Abhinav Diwan, Wolfgang A. Linke, João Pedro Ferreira, Guido Guido Kroemer, Simon Sedej (2025). Autophagy is required for the therapeutic effects of the NAD+ precursor nicotinamide in obesity-related heart failure with preserved ejection fraction. , DOI: https://doi.org/10.1093/eurheartj/ehaf062.
Article72 days agoRoadmap for alleviating the manifestations of ageing in the cardiovascular system
Luca Liberale, Simon Tual‐Chalot, Simon Sedej, Stefano Ministrini, Georgios Georgiopoulos, Myriam Grunewald, Magnus Bäck, Marie‐Luce Bochaton‐Piallat, Reinier A. Boon, Gustavo Ramos, Menno P.J. de Winther, Konstantinos Drosatos, Paul C. Evans, Jane F. Ferguson, Sofia K. Forslund, Claudia Goettsch, Mauro Giacca, Judith Haendeler, Marinos Kallikourdis, Daniel F.J. Ketelhuth, Rory R. Koenen, P. Lacolley, Esther Lutgens, Pasquale Maffia, Satomi Miwa, Claudia Monaco, Fabrizio Montecucco, Giuseppe Danilo Norata, Elena Osto, Gavin D. Richardson, Niels P. Riksen, Oliver Soehnlein, Ioakim Spyridopoulos, Sophie Van Linthout, Gemma Vilahur, Jolanda J. Wentzel, Vicente Andrés, Lina Badimón, A. Benetos, Christoph J. Binder, Ralf P. Brandes, Filippo Crea, David Furman, Vera Gorbunova, Tomasz J Guzik, Joseph A. Hill, Thomas F. Lüscher, Marı́a Mittelbrunn, Alessio Nencioni, Mihai G. Netea, João F. Passos, Kimon Stamatelopoulos, Nektarios Tavernarakis, Zoltán Ungvári, Joseph C. Wu, James L. Kirkland, Giovanni G. Camici, Stefanie Dimmeler, Guido Guido Kroemer, Mahmoud Abdellatif, Konstantinos Stellos (2025). Roadmap for alleviating the manifestations of ageing in the cardiovascular system. , DOI: https://doi.org/10.1038/s41569-025-01130-5.
Article72 days agoNAD <sup>+</sup> repletion restores cardioprotective autophagy and mitophagy in obesity-associated heart failure by suppressing excessive trophic signaling
Mahmoud Abdellatif, Francisco Vasques-Nóvoa, João Pedro Ferreira, Junichi Sadoshima, Abhinav Diwan, Wolfgang A. Linke, Guido Guido Kroemer, Simon Sedej (2025). NAD <sup>+</sup> repletion restores cardioprotective autophagy and mitophagy in obesity-associated heart failure by suppressing excessive trophic signaling. , DOI: https://doi.org/10.1080/15548627.2025.2522127.
Article72 days agoSpermidine is essential for fasting-mediated autophagy and longevity
Sebastian J. Hofer, Ioanna Daskalaki, Martina Bergmann, Jasna Friščić, Andreas Zimmermann, Melanie I. Mueller, Mahmoud Abdellatif, Raffaele Nicastro, Sarah Masser, Sylvère Durand, Alexander Nartey, Mara Waltenstorfer, Sarah Enzenhofer, Isabella Faimann, Verena Gschiel, Thomas Bajaj, Christine Niemeyer, Ilias Gkikas, Lukas Pein, Giulia Cerrato, Hui Pan, YongTian Liang, Jelena Tadić, Andrea Jerkovic, Fanny Aprahamian, Christine Robbins, Nitharsshini Nirmalathasan, Hansjörg Habisch, Elisabeth Annerer, Frederik Dethloff, Michael Stumpe, Franziska Grundler, Françoise Wilhelmi de Toledo, Daniel E. Heinz, Daniela A. Koppold, Anika Rajput Khokhar, Andreas Michalsen, Norbert J. Tripolt, Harald Sourij, Thomas R. Pieber, Rafael de Cabo, Mark A. McCormick, Christoph Magnes, Oliver Kepp, Jörn Dengjel, Stephan J. Sigrist, Nils C. Gassen, Simon Sedej, Tobias Madl, Claudio De Virgilio, Ulrich Stelzl, Markus Hoffmann, Tobias Eisenberg, Nektarios Tavernarakis, Guido Guido Kroemer, Frank Madeo (2024). Spermidine is essential for fasting-mediated autophagy and longevity. , 26(9), DOI: https://doi.org/10.1038/s41556-024-01468-x.
Article72 days agoHallmarks of cardiovascular ageing
Mahmoud Abdellatif, Peter P. Rainer, Simon Sedej, Guido Guido Kroemer (2023). Hallmarks of cardiovascular ageing. , 20(11), DOI: https://doi.org/10.1038/s41569-023-00881-3.
Article72 days ago