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Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes
Seth L. Masters, Aisling Dunne, Shoba Subramanian, Rebecca L. Hull, Gillian M. Tannahill, Fiona A. Sharp, Christine Becker, Luigi Franchi, Eiji Yoshihara, Zhe Chen, N Mullooly, Lisa A. Mielke, James Harris, Rebecca C. Coll, Kingston H. G. Mills, K. Hun Mok, Philip Newsholme, Gabriel Nuñez, Junji Yodoi, Steven E. Kahn, Ed C. Lavelle, Luke O'neill (2010). Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes. Nature Immunology, 11(10), pp. 897-904, DOI: 10.1038/ni.1935.
Article167 days agoUptake of particulate vaccine adjuvants by dendritic cells activates the NALP3 inflammasome
Fiona A. Sharp, Darren Ruane, Benjamin Claass, Emma M. Creagh, James Harris, Padma Malyala, Manomohan Singh, Derek T. O’Hagan, Virginie Pétrilli, Jürg Tschopp, Luke O'neill, Ed C. Lavelle (2009). Uptake of particulate vaccine adjuvants by dendritic cells activates the NALP3 inflammasome. Proceedings of the National Academy of Sciences, 106(3), pp. 870-875, DOI: 10.1073/pnas.0804897106.
Article167 days agoA Common Variant in the Adaptor Mal Regulates Interferon Gamma Signaling
Clíona Ní Cheallaigh, Frederick J. Sheedy, James Harris, Natalia Muñoz‐Wolf, Jinhee Lee, Kim West, Eva M. Pålsson‐McDermott, Alicia Smyth, Laura E. Gleeson, Michelle M. Coleman, Núria Martínez, Claire H. Hearnden, Graham A. Tynan, Elizabeth C. Carroll, Sarah A. Jones, Sinéad C. Corr, Nicholas J. Bernard, Mark Hughes, Sarah E. Corcoran, Mary P. O’Sullivan, Ciara M. Fallon, Hardy Kornfeld, Douglas T. Golenbock, Stephen V. Gordon, Luke O'neill, Ed C. Lavelle, Joseph Keane (2016). A Common Variant in the Adaptor Mal Regulates Interferon Gamma Signaling. Immunity, 44(2), pp. 368-379, DOI: 10.1016/j.immuni.2016.01.019.
Article167 days ago