0 Datasets
0 Files
Get instant academic access to this publication’s datasets.
Yes. After verification, you can browse and download datasets at no cost. Some premium assets may require author approval.
Files are stored on encrypted storage. Access is restricted to verified users and all downloads are logged.
Yes, message the author after sign-up to request supplementary files or replication code.
Join 50,000+ researchers worldwide. Get instant access to peer-reviewed datasets, advanced analytics, and global collaboration tools.
✓ Immediate verification • ✓ Free institutional access • ✓ Global collaborationJoin our academic network to download verified datasets and collaborate with researchers worldwide.
Get Free AccessHumans that are heterozygous for the common S180L polymorphism in the Toll-like receptor (TLR) adaptor Mal (encoded by TIRAP) are protected from a number of infectious diseases, including tuberculosis (TB), whereas those homozygous for the allele are at increased risk. The reason for this difference in susceptibility is not clear. We report that Mal has a TLR-independent role in interferon-gamma (IFN-γ) receptor signaling. Mal-dependent IFN-γ receptor (IFNGR) signaling led to mitogen-activated protein kinase (MAPK) p38 phosphorylation and autophagy. IFN-γ signaling via Mal was required for phagosome maturation and killing of intracellular Mycobacterium tuberculosis (Mtb). The S180L polymorphism, and its murine equivalent S200L, reduced the affinity of Mal for the IFNGR, thereby compromising IFNGR signaling in macrophages and impairing responses to TB. Our findings highlight a role for Mal outside the TLR system and imply that genetic variation in TIRAP may be linked to other IFN-γ-related diseases including autoimmunity and cancer.
Clíona Ní Cheallaigh, Frederick J. Sheedy, James Harris, Natalia Muñoz‐Wolf, Jinhee Lee, Kim West, Eva M. Pålsson‐McDermott, Alicia Smyth, Laura E. Gleeson, Michelle M. Coleman, Núria Martínez, Claire H. Hearnden, Graham A. Tynan, Elizabeth C. Carroll, Sarah A. Jones, Sinéad C. Corr, Nicholas J. Bernard, Mark Hughes, Sarah E. Corcoran, Mary P. O’Sullivan, Ciara M. Fallon, Hardy Kornfeld, Douglas T. Golenbock, Stephen V. Gordon, Luke O'neill, Ed C. Lavelle, Joseph Keane (2016). A Common Variant in the Adaptor Mal Regulates Interferon Gamma Signaling. Immunity, 44(2), pp. 368-379, DOI: 10.1016/j.immuni.2016.01.019.
Datasets shared by verified academics with rich metadata and previews.
Authors choose access levels; downloads are logged for transparency.
Students and faculty get instant access after verification.
Type
Article
Year
2016
Authors
27
Datasets
0
Total Files
0
Language
English
Journal
Immunity
DOI
10.1016/j.immuni.2016.01.019
Access datasets from 50,000+ researchers worldwide with institutional verification.
Get Free Access
.jpg){kind=avatar}
