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Pyruvate Kinase M2 Regulates Hif-1α Activity and IL-1β Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages
Eva M. Pålsson‐McDermott, Annie M. Curtis, Gautam Goel, Mario A. Lauterbach, Frederick J. Sheedy, Laura E. Gleeson, Mirjam W.M. van den Bosch, Susan R. Quinn, Raquel Domingo-Fernandéz, Daniel Johnston, Jian‐kang Jiang, William J. Israelsen, Joseph Keane, Craig J. Thomas, Clary B. Clish, Matthew G. Vander Heiden, Ramnik J. Xavier, Luke O'neill (2015). Pyruvate Kinase M2 Regulates Hif-1α Activity and IL-1β Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages. Cell Metabolism, 21(1), pp. 65-80, DOI: 10.1016/j.cmet.2014.12.005.
Article167 days agoNegative regulation of TLR4 via targeting of the proinflammatory tumor suppressor PDCD4 by the microRNA miR-21
Frederick J. Sheedy, Eva M. Pålsson‐McDermott, Elizabeth J. Hennessy, Cara Martin, John O’Leary, Qingguo Ruan, Derek Johnson, Youhai Chen, Luke O'neill (2009). Negative regulation of TLR4 via targeting of the proinflammatory tumor suppressor PDCD4 by the microRNA miR-21. Nature Immunology, 11(2), pp. 141-147, DOI: 10.1038/ni.1828.
Article167 days agoMicroRNAs: the fine-tuners of Toll-like receptor signalling
Luke O'neill, Frederick J. Sheedy, Claire E. McCoy (2011). MicroRNAs: the fine-tuners of Toll-like receptor signalling. Nature reviews. Immunology, 11(3), pp. 163-175, DOI: 10.1038/nri2957.
Article167 days agoCutting Edge: <i>Mycobacterium tuberculosis</i> Induces Aerobic Glycolysis in Human Alveolar Macrophages That Is Required for Control of Intracellular Bacillary Replication
Laura E. Gleeson, Frederick J. Sheedy, Eva M. Pålsson‐McDermott, Denise Triglia, Seónadh M. O’Leary, Mary P. O’Sullivan, Luke O'neill, Joseph Keane (2016). Cutting Edge: <i>Mycobacterium tuberculosis</i> Induces Aerobic Glycolysis in Human Alveolar Macrophages That Is Required for Control of Intracellular Bacillary Replication. The Journal of Immunology, 196(6), pp. 2444-2449, DOI: 10.4049/jimmunol.1501612.
Article167 days agoIL-10 Inhibits miR-155 Induction by Toll-like Receptors
Claire E. McCoy, Frederick J. Sheedy, Joseph E. Qualls, Sarah Doyle, Susan R. Quinn, Peter J. Murray, Luke O'neill (2010). IL-10 Inhibits miR-155 Induction by Toll-like Receptors. Journal of Biological Chemistry, 285(27), pp. 20492-20498, DOI: 10.1074/jbc.m110.102111.
Article167 days ago