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The last 5 uploaded publications
Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1
Evanna L. Mills, Dylan G. Ryan, Hiran A. Prag, Dina Dikovskaya, Deepthi Menon, Zbigniew Zasłona, Mark P. Jedrychowski, Ana S.H. Costa, Maureen Higgins, Emily Hams, John Szpyt, Marah C. Runtsch, Martin S. King, Joanna F. McGouran, Román Fischer, Benedikt M. Kessler, Anne F. McGettrick, Mark Hughes, Richard G. Carroll, Lee M. Booty, Elena V. Knatko, Paul J. Meakin, Michael L.J. Ashford, Louise K. Modis, Gino Brunori, Daniel C. Sévin, Padraic G. Fallon, Stuart T. Caldwell, Edmund R.S. Kunji, Edward T. Chouchani, Christian Frezza, Albena T. Dinkova‐Kostova, Richard C. Hartley, Michael P. Murphy, Luke O'neill (2018). Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1. Nature, 556(7699), pp. 113-117, DOI: 10.1038/nature25986.
Article167 days agoCircadian clock protein BMAL1 regulates IL-1β in macrophages via NRF2
James O. Early, Deepthi Menon, Cathy Wyse, Mariana P. Cervantes‐Silva, Zbigniew Zasłona, Richard G. Carroll, Eva M. Pålsson‐McDermott, Stefano Angiari, Dylan G. Ryan, Sarah E. Corcoran, George A. Timmons, Sarah S. Geiger, Darren J. Fitzpatrick, Daniel J. O’Connell, Ramnik J. Xavier, Karsten Hokamp, Luke O'neill, Annie M. Curtis (2018). Circadian clock protein BMAL1 regulates IL-1β in macrophages via NRF2. Proceedings of the National Academy of Sciences, 115(36), DOI: 10.1073/pnas.1800431115.
Article167 days agoCytokine-like Roles for Metabolites in Immunity
Zbigniew Zasłona, Luke O'neill (2020). Cytokine-like Roles for Metabolites in Immunity. Molecular Cell, 78(5), pp. 814-823, DOI: 10.1016/j.molcel.2020.04.002.
Article167 days agoAn unexpected link between fatty acid synthase and cholesterol synthesis in proinflammatory macrophage activation
Richard G. Carroll, Zbigniew Zasłona, Silvia Galván-Peña, Emma Koppe, Daniel C. Sévin, Stefano Angiari, Martha Triantafilou, Kathy Triantafilou, Louise K. Modis, Luke O'neill (2018). An unexpected link between fatty acid synthase and cholesterol synthesis in proinflammatory macrophage activation. Journal of Biological Chemistry, 293(15), pp. 5509-5521, DOI: 10.1074/jbc.ra118.001921.
Article167 days agoPyruvate Kinase M2 Is Required for the Expression of the Immune Checkpoint PD-L1 in Immune Cells and Tumors
Eva M. Pålsson‐McDermott, Lydia Dyck, Zbigniew Zasłona, Deepthi Menon, Anne F. McGettrick, Kingston H. G. Mills, Luke O'neill (2017). Pyruvate Kinase M2 Is Required for the Expression of the Immune Checkpoint PD-L1 in Immune Cells and Tumors. Frontiers in Immunology, 8, DOI: 10.3389/fimmu.2017.01300.
Article167 days ago