Loading publications…
The last 5 uploaded publications
Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages
Evanna L. Mills, Beth Kelly, Angela Logan, Ana S.H. Costa, Mukund Varma, Clare Bryant, Panagiotis Tourlomousis, J. Henry M. Däbritz, Eyal Gottlieb, Isabel Latorre, Sinéad C. Corr, Gavin McManus, Dylan G. Ryan, Howard T. Jacobs, Marten Szibor, Ramnik J. Xavier, Thomas Braun, Christian Frezza, Michael P. Murphy, Luke O'neill (2016). Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages. Cell, 167(2), pp. 457-470.e13, DOI: 10.1016/j.cell.2016.08.064.
Article167 days agoItaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1
Evanna L. Mills, Dylan G. Ryan, Hiran A. Prag, Dina Dikovskaya, Deepthi Menon, Zbigniew Zasłona, Mark P. Jedrychowski, Ana S.H. Costa, Maureen Higgins, Emily Hams, John Szpyt, Marah C. Runtsch, Martin S. King, Joanna F. McGouran, Román Fischer, Benedikt M. Kessler, Anne F. McGettrick, Mark Hughes, Richard G. Carroll, Lee M. Booty, Elena V. Knatko, Paul J. Meakin, Michael L.J. Ashford, Louise K. Modis, Gino Brunori, Daniel C. Sévin, Padraic G. Fallon, Stuart T. Caldwell, Edmund R.S. Kunji, Edward T. Chouchani, Christian Frezza, Albena T. Dinkova‐Kostova, Richard C. Hartley, Michael P. Murphy, Luke O'neill (2018). Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1. Nature, 556(7699), pp. 113-117, DOI: 10.1038/nature25986.
Article167 days agoKrebs Cycle Reborn in Macrophage Immunometabolism
Dylan G. Ryan, Luke O'neill (2020). Krebs Cycle Reborn in Macrophage Immunometabolism. Annual Review of Immunology, 38(1), pp. 289-313, DOI: 10.1146/annurev-immunol-081619-104850.
Article167 days agoCoupling Krebs cycle metabolites to signalling in immunity and cancer
Dylan G. Ryan, Michael P. Murphy, Christian Frezza, Hiran A. Prag, Edward T. Chouchani, Luke O'neill, Evanna L. Mills (2018). Coupling Krebs cycle metabolites to signalling in immunity and cancer. Nature Metabolism, 1(1), pp. 16-33, DOI: 10.1038/s42255-018-0014-7.
Article167 days agoCircadian clock protein BMAL1 regulates IL-1β in macrophages via NRF2
James O. Early, Deepthi Menon, Cathy Wyse, Mariana P. Cervantes‐Silva, Zbigniew Zasłona, Richard G. Carroll, Eva M. Pålsson‐McDermott, Stefano Angiari, Dylan G. Ryan, Sarah E. Corcoran, George A. Timmons, Sarah S. Geiger, Darren J. Fitzpatrick, Daniel J. O’Connell, Ramnik J. Xavier, Karsten Hokamp, Luke O'neill, Annie M. Curtis (2018). Circadian clock protein BMAL1 regulates IL-1β in macrophages via NRF2. Proceedings of the National Academy of Sciences, 115(36), DOI: 10.1073/pnas.1800431115.
Article167 days ago