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Autophagy is required for the therapeutic effects of the NAD+ precursor nicotinamide in obesity-related heart failure with preserved ejection fraction
Mahmoud Abdellatif, Francisco Vasques‐Nóvoa, Viktoria Trummer-Herbst, Sylvère Durand, Franziska Koser, Moydul Islam, Jihoon Nah, Eun‐Ah Sung, Ruli Feng, Fanny Aprahamian, Andreas Prokesch, Andreas Prokesch, Junichi Sadoshima, Abhinav Diwan, Wolfgang A. Linke, João Pedro Ferreira, Guido Guido Kroemer, Simon Sedej (2025). Autophagy is required for the therapeutic effects of the NAD+ precursor nicotinamide in obesity-related heart failure with preserved ejection fraction. , DOI: https://doi.org/10.1093/eurheartj/ehaf062.
Article73 days agoNAD <sup>+</sup> repletion restores cardioprotective autophagy and mitophagy in obesity-associated heart failure by suppressing excessive trophic signaling
Mahmoud Abdellatif, Francisco Vasques-Nóvoa, João Pedro Ferreira, Junichi Sadoshima, Abhinav Diwan, Wolfgang A. Linke, Guido Guido Kroemer, Simon Sedej (2025). NAD <sup>+</sup> repletion restores cardioprotective autophagy and mitophagy in obesity-associated heart failure by suppressing excessive trophic signaling. , DOI: https://doi.org/10.1080/15548627.2025.2522127.
Article73 days agoMetabolic control of mitophagy
Andreas Zimmermann, Frank Madeo, Abhinav Diwan, Junichi Sadoshima, Simon Sedej, Guido Guido Kroemer, Mahmoud Abdellatif (2023). Metabolic control of mitophagy. , 54(4), DOI: https://doi.org/10.1111/eci.14138.
Article73 days agoFine-Tuning Cardiac Insulin-Like Growth Factor 1 Receptor Signaling to Promote Health and Longevity
Mahmoud Abdellatif, Viktoria Trummer-Herbst, Alexander Martin Heberle, Alina Humnig, Tobias Pendl, Sylvère Durand, Giulia Cerrato, Sebastian J. Hofer, Moydul Islam, Julia Voglhuber, José M. Ramos Pittol, Oliver Kepp, Gerald Höefler, Albrecht Schmidt, Peter P. Rainer, Douglas S. Scherr, Dirk von Lewinski, Egbert Bisping, Julie R. McMullen, Abhinav Diwan, Tobias Eisenberg, Frank Madeo, Kathrin Thedieck, Guido Guido Kroemer, Simon Sedej (2022). Fine-Tuning Cardiac Insulin-Like Growth Factor 1 Receptor Signaling to Promote Health and Longevity. , 145(25), DOI: https://doi.org/10.1161/circulationaha.122.059863.
Article73 days ago