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The last 5 uploaded publications
Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages
Evanna L. Mills, Beth Kelly, Angela Logan, Ana S.H. Costa, Mukund Varma, Clare Bryant, Panagiotis Tourlomousis, J. Henry M. Däbritz, Eyal Gottlieb, Isabel Latorre, Sinéad C. Corr, Gavin McManus, Dylan G. Ryan, Howard T. Jacobs, Marten Szibor, Ramnik J. Xavier, Thomas Braun, Christian Frezza, Michael P. Murphy, Luke O'neill (2016). Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages. Cell, 167(2), pp. 457-470.e13, DOI: 10.1016/j.cell.2016.08.064.
Article167 days agoItaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1
Evanna L. Mills, Dylan G. Ryan, Hiran A. Prag, Dina Dikovskaya, Deepthi Menon, Zbigniew Zasłona, Mark P. Jedrychowski, Ana S.H. Costa, Maureen Higgins, Emily Hams, John Szpyt, Marah C. Runtsch, Martin S. King, Joanna F. McGouran, Román Fischer, Benedikt M. Kessler, Anne F. McGettrick, Mark Hughes, Richard G. Carroll, Lee M. Booty, Elena V. Knatko, Paul J. Meakin, Michael L.J. Ashford, Louise K. Modis, Gino Brunori, Daniel C. Sévin, Padraic G. Fallon, Stuart T. Caldwell, Edmund R.S. Kunji, Edward T. Chouchani, Christian Frezza, Albena T. Dinkova‐Kostova, Richard C. Hartley, Michael P. Murphy, Luke O'neill (2018). Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1. Nature, 556(7699), pp. 113-117, DOI: 10.1038/nature25986.
Article167 days agoCoupling Krebs cycle metabolites to signalling in immunity and cancer
Dylan G. Ryan, Michael P. Murphy, Christian Frezza, Hiran A. Prag, Edward T. Chouchani, Luke O'neill, Evanna L. Mills (2018). Coupling Krebs cycle metabolites to signalling in immunity and cancer. Nature Metabolism, 1(1), pp. 16-33, DOI: 10.1038/s42255-018-0014-7.
Article167 days agoKrebs Cycle Reimagined: The Emerging Roles of Succinate and Itaconate as Signal Transducers
Michael P. Murphy, Luke O'neill (2018). Krebs Cycle Reimagined: The Emerging Roles of Succinate and Itaconate as Signal Transducers. Cell, 174(4), pp. 780-784, DOI: 10.1016/j.cell.2018.07.030.
Article167 days agoMetformin Inhibits the Production of Reactive Oxygen Species from NADH:Ubiquinone Oxidoreductase to Limit Induction of Interleukin-1β (IL-1β) and Boosts Interleukin-10 (IL-10) in Lipopolysaccharide (LPS)-activated Macrophages
Beth Kelly, Gillian M. Tannahill, Michael P. Murphy, Luke O'neill (2015). Metformin Inhibits the Production of Reactive Oxygen Species from NADH:Ubiquinone Oxidoreductase to Limit Induction of Interleukin-1β (IL-1β) and Boosts Interleukin-10 (IL-10) in Lipopolysaccharide (LPS)-activated Macrophages. Journal of Biological Chemistry, 290(33), pp. 20348-20359, DOI: 10.1074/jbc.m115.662114.
Article167 days ago