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The last 5 uploaded publications
Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1
Evanna L. Mills, Dylan G. Ryan, Hiran A. Prag, Dina Dikovskaya, Deepthi Menon, Zbigniew Zasłona, Mark P. Jedrychowski, Ana S.H. Costa, Maureen Higgins, Emily Hams, John Szpyt, Marah C. Runtsch, Martin S. King, Joanna F. McGouran, Román Fischer, Benedikt M. Kessler, Anne F. McGettrick, Mark Hughes, Richard G. Carroll, Lee M. Booty, Elena V. Knatko, Paul J. Meakin, Michael L.J. Ashford, Louise K. Modis, Gino Brunori, Daniel C. Sévin, Padraic G. Fallon, Stuart T. Caldwell, Edmund R.S. Kunji, Edward T. Chouchani, Christian Frezza, Albena T. Dinkova‐Kostova, Richard C. Hartley, Michael P. Murphy, Luke O'neill (2018). Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1. Nature, 556(7699), pp. 113-117, DOI: 10.1038/nature25986.
Article167 days agoCircadian clock protein BMAL1 regulates IL-1β in macrophages via NRF2
James O. Early, Deepthi Menon, Cathy Wyse, Mariana P. Cervantes‐Silva, Zbigniew Zasłona, Richard G. Carroll, Eva M. Pålsson‐McDermott, Stefano Angiari, Dylan G. Ryan, Sarah E. Corcoran, George A. Timmons, Sarah S. Geiger, Darren J. Fitzpatrick, Daniel J. O’Connell, Ramnik J. Xavier, Karsten Hokamp, Luke O'neill, Annie M. Curtis (2018). Circadian clock protein BMAL1 regulates IL-1β in macrophages via NRF2. Proceedings of the National Academy of Sciences, 115(36), DOI: 10.1073/pnas.1800431115.
Article167 days agoMalonylation of GAPDH is an inflammatory signal in macrophages
Silvia Galván-Peña, Richard G. Carroll, Carla F. Newman, Elizabeth C. Hinchy, Eva M. Pålsson‐McDermott, Elektra K. Robinson, Sergio Covarrubias, Alan Nadin, Andrew M. James, Moritz Haneklaus, Susan Carpenter, Vincent P. Kelly, Michael P. Murphy, Louise K. Modis, Luke O'neill (2019). Malonylation of GAPDH is an inflammatory signal in macrophages. Nature Communications, 10(1), DOI: 10.1038/s41467-018-08187-6.
Article167 days agoAn unexpected link between fatty acid synthase and cholesterol synthesis in proinflammatory macrophage activation
Richard G. Carroll, Zbigniew Zasłona, Silvia Galván-Peña, Emma Koppe, Daniel C. Sévin, Stefano Angiari, Martha Triantafilou, Kathy Triantafilou, Louise K. Modis, Luke O'neill (2018). An unexpected link between fatty acid synthase and cholesterol synthesis in proinflammatory macrophage activation. Journal of Biological Chemistry, 293(15), pp. 5509-5521, DOI: 10.1074/jbc.ra118.001921.
Article167 days agoCaspase-11 promotes allergic airway inflammation
Zbigniew Zasłona, Ewelina Flis, Mieszko M. Wilk, Richard G. Carroll, Eva M. Pålsson‐McDermott, Mark Hughes, Ciana Diskin, Kathy Banahan, Dylan G. Ryan, Alexander Hooftman, Alicja Misiak, Jay Kearney, Günter Lochnit, Wilhelm Bertrams, Timm Greulich, Bernd Schmeck, Oliver J. McElvaney, Kingston H. G. Mills, Ed C. Lavelle, Małgorzata Wygrecka, Emma M. Creagh, Luke O'neill (2020). Caspase-11 promotes allergic airway inflammation. Nature Communications, 11(1), DOI: 10.1038/s41467-020-14945-2.
Article167 days ago