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The last 5 uploaded publications
Human-correlated genetic models identify precision therapy for liver cancer
Miryam Müller, Stephanie May, H. G. HALL, Timothy J. Kendall, Lynn McGarry, Lauriane Blukacz, Sandro Nuciforo, Αναστασία Γεωργακοπούλου, Thomas Jamieson, Narisa Phinichkusolchit, Sandeep Dhayade, Toshiyasu Suzuki, Júlia Huguet‐Pradell, Ian R. Powley, Leah Officer-Jones, Rachel Pennie, Roger Esteban-Fabró, Albert Gris‐Oliver, Roser Pinyol, George Skalka, Jack Leslie, Matthew Hoare, Joep Sprangers, Gaurav Malviya, Agata Mackintosh, Emma Johnson, Misti McCain, John Halpin, Christos Kiourtis, Colin Nixon, Graeme M. Clark, William R. Clark, Robin Shaw, Ann Hedley, Thomas M. Drake, Ee Hong Tan, Matt Neilson, Daniel J. Murphy, David Y. Lewis, Helen L. Reeves, John Le Quesne, Derek A. Mann, Leo M. Carlin, Karen Blyth, Josep M. Llovet, Markus H. Heim, Owen J. Sansom, Crispin Miller, Thomas G. Bird (2025). Human-correlated genetic models identify precision therapy for liver cancer. Nature, DOI: 10.1038/s41586-025-08585-z.
Article355 days agoTHU-077-YI E7386 enhances lenvatinib’s antitumor efficacy and upregulates ATF4 signalling in preclinical models and human hepatocellular carcinoma
Agavni Mesropian, Albert Gris‐Oliver, Ugne Balaseviciute, Martí Torres-Marcen, Jordi Abril‐Fornaguera, Marta Piqué‐Gili, David Camell, Judit Peix, Elisa Fernández-Martínez, Júlia Huguet‐Pradell, Ieva Keraite, Roger Esteban-Fabró, Takayuki Kimura, Alka A. Potdar, Marina Bárcena‐Varela, Katherine E. Lindblad, Amaia Lujambio, Ernesto Guccione, Swan N. Thung, Daniela Sia, Roser Pinyol, Josep M. Llovet (2025). THU-077-YI E7386 enhances lenvatinib’s antitumor efficacy and upregulates ATF4 signalling in preclinical models and human hepatocellular carcinoma. Journal of Hepatology, 82, pp. S431-S432, DOI: 10.1016/s0168-8278(25)01237-1.
Article355 days agoTOP-128-YI Efficacy of WNTinib, a novel selective therapeutic for CTNNB1mutant tumors, in preclinical models of hepatoblastoma
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Elisa Fernández-Martínez, Albert Gris‐Oliver, Roser Pinyol, Alex Rialdi, Agavni Mesropian, Gulay Ulukaya, Dan Hasson, Ieva Keraite, Swan N. Thung, Ernesto Guccione, Josep M. Llovet (2025). TOP-128-YI Efficacy of WNTinib, a novel selective therapeutic for CTNNB1mutant tumors, in preclinical models of hepatoblastoma. Journal of Hepatology, 82, pp. S429-S429, DOI: 10.1016/s0168-8278(25)01230-9.
Article355 days agoSingle-cell RNA seq-derived signatures define response patterns to atezolizumab + bevacizumab in advanced hepatocellular carcinoma
Sarah Cappuyns, Marta Piqué‐Gili, Roger Esteban-Fabró, Gino Philips, Ugne Balaseviciute, Roser Pinyol, Albert Gris‐Oliver, Vincent Vandecaveye, Jordi Abril‐Fornaguera, Carla Montironi, Laia Bassaganyas, Judit Peix, Marcus Zeitlhöfler, Agavni Mesropian, Júlia Huguet‐Pradell, Philipp K. Haber, Igor Figueiredo, Giorgio Ioannou, Edgar Gonzalez‐Kozlova, Antonio D’Alessio, Raphael Mohr, Tim Meyer, Anja Lachenmayer, Jens U. Marquardt, Helen L. Reeves, Julien Edeline, Fabian Finkelmeier, Jörg Trojan, Peter R. Galle, Friedrich Foerster, Beatriz Mínguez, Robert Montal, Sacha Gnjatic, David J. Pinato, Mathias Heikenwälder, Chris Verslype, Eric Van Cutsem, Diether Lambrechts, Augusto Villanueva, Jeroen Dekervel, Josep M. Llovet (2024). Single-cell RNA seq-derived signatures define response patterns to atezolizumab + bevacizumab in advanced hepatocellular carcinoma. Journal of Hepatology, DOI: 10.1016/j.jhep.2024.12.016.
Article355 days agoFRI-467 Efficacy of WNTinib, a novel selective therapeutic for CTNNB1 mutant tumors, in preclinical models of hepatoblastoma
Ugne Balaseviciute, Jordi Abril‐Fornaguera, Júlia Huguet‐Pradell, Alex Rialdi, Elisa Fernández-Martínez, Albert Gris‐Oliver, Agavni Mesropian, Gulay Ulukaya, Dan Hasson, Ieva Keraite, Roser Pinyol, Swan N. Thung, Ernesto Guccione, Josep M. Llovet (2024). FRI-467 Efficacy of WNTinib, a novel selective therapeutic for CTNNB1 mutant tumors, in preclinical models of hepatoblastoma. Journal of Hepatology, 80, pp. S417-S418, DOI: 10.1016/s0168-8278(24)01331-x.
Article355 days ago