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Targeting the ER stress sensor IRE1 protects the liver from fibrosis through the downregulation of the proteostasis factor P4HB/PDIA1
Younis Hazari, Lama Habbouche, Valeria A. Garcia Lopez, Hery Urra, Javier Diaz, Giovanni Tamburini, Mateus Milani, Sylvère Durand, Fanny Aprahamian, Reese Baxter, Menghao Huang, X. Charlie Dong, Luis González-Rojas, Jorge F. Silva, Ignacio Tapia-Dufey, Helena Vihinen, Vlad Ratziu, Fabienne Foufelle, Jan G. Hengstler, Eija Jokitalo, Jessica L. Maiers, Lars Plate, Guido Guido Kroemer, Béatrice Bailly-Maître, Claudio Hetz (2025). Targeting the ER stress sensor IRE1 protects the liver from fibrosis through the downregulation of the proteostasis factor P4HB/PDIA1. , DOI: https://doi.org/10.1097/hep.0000000000001335.
Article73 days agoAuthor Reply to Peer Reviews of Targeting the ER stress sensor IRE1 protects the liver from fibrosis through the downregulation of the proteostasis factor P4HB/PDIA1
Younis Hazari, Hery Urra, Valeria A. Garcia Lopez, Lama Habbouche, Javier Diaz, Giovanni Tamburini, Mateus Milani, Philippe Pihán, Sylvère Durand, Fanny Aprahamian, Reese Baxter, Menghao Huang, Xiulin Dong, Helena Vihinen, Ana Batista Gonzalez, Patrício Godoy, Alfredo Criollo, Vlad Ratziu, Fabienne Foufelle, Jan G. Hengstler, Eija Jokitalo, Jessica L. Maiers, Lars Plate, Guido Guido Kroemer, Béatrice Bailly-Maître, Claudio Hetz (2024). Author Reply to Peer Reviews of Targeting the ER stress sensor IRE1 protects the liver from fibrosis through the downregulation of the proteostasis factor P4HB/PDIA1. , DOI: https://doi.org/10.15252/rc.2024283700.
Preprint73 days agoThe endoplasmic reticulum stress sensor IRE1 regulates collagen secretion through the enforcement of the proteostasis factor P4HB/PDIA1 contributing to liver damage and fibrosis
Younis Hazari, Hery Urra, Valeria A. Garcia Lopez, Javier Diaz, Giovanni Tamburini, Mateus Milani, Philippe Pihán, Sylvère Durand, Fanny Aprahamia, Reese Baxter, Menghao Huang, Xiaonan Dong, Helena Vihinen, Ana Batista-Gonzalez, Patrício Godoy, Alfredo Criollo, Vlad Ratziu, Fabienne Foufelle, Jan G. Hengstler, Eija Jokitalo, Béatrice Bailly-Maître, Jessica L. Maiers, Lars Plate, Guido Guido Kroemer, Claudio Hetz (2023). The endoplasmic reticulum stress sensor IRE1 regulates collagen secretion through the enforcement of the proteostasis factor P4HB/PDIA1 contributing to liver damage and fibrosis. , DOI: https://doi.org/10.1101/2023.05.02.538835.
Preprint73 days agoAutophagy in hepatic adaptation to stress
Younis Hazari, José Manuel Bravo‐San Pedro, Claudio Hetz, Lorenzo Galluzzi, Guido Guido Kroemer (2019). Autophagy in hepatic adaptation to stress. , 72(1), DOI: https://doi.org/10.1016/j.jhep.2019.08.026.
Article73 days agoGenotoxic stress triggers the activation of IRE1α-dependent RNA decay to modulate the DNA damage response
Estefanie Dufey, José Manuel Bravo‐San Pedro, Cristián Eggers, Matías González-Quiroz, Hery Urra, Alfredo Sagredo, Denisse Sepúlveda, Philippe Pihán, Amado Carreras-Sureda, Younis Hazari, Eduardo A. Sagredo, Daniela Gutiérrez, Cristian Valls, Alexandra Papaioannou, Diego Acosta‐Alvear, Gisela Campos, Pedro Domingos, Rémy Pedeux, Éric Chevet, Alejandra Álvarez, Patrício Godoy, Peter Walter, Álvaro Glavic, Guido Guido Kroemer, Claudio Hetz (2020). Genotoxic stress triggers the activation of IRE1α-dependent RNA decay to modulate the DNA damage response. , 11(1), DOI: https://doi.org/10.1038/s41467-020-15694-y.
Article73 days ago