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The last 5 uploaded publications
HIF1α and metabolic reprogramming in inflammation
Sarah E. Corcoran, Luke O'neill (2016). HIF1α and metabolic reprogramming in inflammation. Journal of Clinical Investigation, 126(10), pp. 3699-3707, DOI: 10.1172/jci84431.
Article168 days agoThe Immunomodulatory Metabolite Itaconate Modifies NLRP3 and Inhibits Inflammasome Activation
Alexander Hooftman, Stefano Angiari, Svenja Hester, Sarah E. Corcoran, Marah C. Runtsch, Chris Ling, Melanie C. Ruzek, Peter F. Slivka, Anne F. McGettrick, Kathy Banahan, Mark Hughes, Alan D. Irvine, Román Fischer, Luke O'neill (2020). The Immunomodulatory Metabolite Itaconate Modifies NLRP3 and Inhibits Inflammasome Activation. Cell Metabolism, 32(3), pp. 468-478.e7, DOI: 10.1016/j.cmet.2020.07.016.
Article168 days agoCircadian clock protein BMAL1 regulates IL-1β in macrophages via NRF2
James O. Early, Deepthi Menon, Cathy Wyse, Mariana P. Cervantes‐Silva, Zbigniew Zasłona, Richard G. Carroll, Eva M. Pålsson‐McDermott, Stefano Angiari, Dylan G. Ryan, Sarah E. Corcoran, George A. Timmons, Sarah S. Geiger, Darren J. Fitzpatrick, Daniel J. O’Connell, Ramnik J. Xavier, Karsten Hokamp, Luke O'neill, Annie M. Curtis (2018). Circadian clock protein BMAL1 regulates IL-1β in macrophages via NRF2. Proceedings of the National Academy of Sciences, 115(36), DOI: 10.1073/pnas.1800431115.
Article168 days agoThe Induction of Pro–IL-1β by Lipopolysaccharide Requires Endogenous Prostaglandin E2 Production
Zbigniew Zasłona, Eva M. Pålsson‐McDermott, Deepthi Menon, Moritz Haneklaus, Ewelina Flis, Hannah Prendeville, Sarah E. Corcoran, Marc Peters‐Golden, Luke O'neill (2017). The Induction of Pro–IL-1β by Lipopolysaccharide Requires Endogenous Prostaglandin E2 Production. The Journal of Immunology, 198(9), pp. 3558-3564, DOI: 10.4049/jimmunol.1602072.
Article168 days agoA Common Variant in the Adaptor Mal Regulates Interferon Gamma Signaling
Clíona Ní Cheallaigh, Frederick J. Sheedy, James Harris, Natalia Muñoz‐Wolf, Jinhee Lee, Kim West, Eva M. Pålsson‐McDermott, Alicia Smyth, Laura E. Gleeson, Michelle M. Coleman, Núria Martínez, Claire H. Hearnden, Graham A. Tynan, Elizabeth C. Carroll, Sarah A. Jones, Sinéad C. Corr, Nicholas J. Bernard, Mark Hughes, Sarah E. Corcoran, Mary P. O’Sullivan, Ciara M. Fallon, Hardy Kornfeld, Douglas T. Golenbock, Stephen V. Gordon, Luke O'neill, Ed C. Lavelle, Joseph Keane (2016). A Common Variant in the Adaptor Mal Regulates Interferon Gamma Signaling. Immunity, 44(2), pp. 368-379, DOI: 10.1016/j.immuni.2016.01.019.
Article168 days ago