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The last 5 uploaded publications
Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction
Katherine A. Fitzgerald, Eva M. Pålsson‐McDermott, Andrew Bowie, Caroline A. Jefferies, Ashley Mansell, Gareth Brady, Elizabeth Brint, Aisling Dunne, Pearl Gray, Mary T. Harte, Diane McMurray, Dirk E. Smith, John E. Sims, Timothy A. Bird, Luke O'neill (2001). Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction. Nature, 413(6851), pp. 78-83, DOI: 10.1038/35092578.
Article167 days agoSuppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation
Ashley Mansell, Rosealee Smith, Sarah Doyle, Pearl Gray, Jennifer E Fenner, Peter J. Crack, Sandra E. Nicholson, Douglas J. Hilton, Luke O'neill, Paul J. Hertzog (2006). Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation. Nature Immunology, 7(2), pp. 148-155, DOI: 10.1038/ni1299.
Article167 days agoMal Interacts with Tumor Necrosis Factor Receptor-associated Factor (TRAF)-6 to mediate NF-κB Activation by Toll-like Receptor (TLR)-2 and TLR4
Ashley Mansell, Elizabeth Brint, Jodee A. Gould, Luke O'neill, Paul J. Hertzog (2004). Mal Interacts with Tumor Necrosis Factor Receptor-associated Factor (TRAF)-6 to mediate NF-κB Activation by Toll-like Receptor (TLR)-2 and TLR4. Journal of Biological Chemistry, 279(36), pp. 37227-37230, DOI: 10.1074/jbc.c400289200.
Article167 days agoSolution structure of the TLR adaptor MAL/TIRAP reveals an intact BB loop and supports MAL Cys91 glutathionylation for signaling
Mark Hughes, Peter Lavrencic, Rebecca C. Coll, Thomas Ve, Dylan G. Ryan, Niamh C. Williams, Deepthi Menon, Ashley Mansell, Philip G. Board, Mehdi Mobli, Boštjan Kobe, Luke O'neill (2017). Solution structure of the TLR adaptor MAL/TIRAP reveals an intact BB loop and supports MAL Cys91 glutathionylation for signaling. Proceedings of the National Academy of Sciences, 114(32), DOI: 10.1073/pnas.1701868114.
Article167 days agoInternalin B Activates Nuclear Factor-κB via Ras, Phosphoinositide 3-Kinase, and Akt
Ashley Mansell, Nadia Khelef, Pascale Cossart, Luke O'neill (2001). Internalin B Activates Nuclear Factor-κB via Ras, Phosphoinositide 3-Kinase, and Akt. Journal of Biological Chemistry, 276(47), pp. 43597-43603, DOI: 10.1074/jbc.m105202200.
Article167 days ago