Loading publications…
The last 5 uploaded publications
Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1
Evanna L. Mills, Dylan G. Ryan, Hiran A. Prag, Dina Dikovskaya, Deepthi Menon, Zbigniew Zasłona, Mark P. Jedrychowski, Ana S.H. Costa, Maureen Higgins, Emily Hams, John Szpyt, Marah C. Runtsch, Martin S. King, Joanna F. McGouran, Román Fischer, Benedikt M. Kessler, Anne F. McGettrick, Mark Hughes, Richard G. Carroll, Lee M. Booty, Elena V. Knatko, Paul J. Meakin, Michael L.J. Ashford, Louise K. Modis, Gino Brunori, Daniel C. Sévin, Padraic G. Fallon, Stuart T. Caldwell, Edmund R.S. Kunji, Edward T. Chouchani, Christian Frezza, Albena T. Dinkova‐Kostova, Richard C. Hartley, Michael P. Murphy, Luke O'neill (2018). Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1. Nature, 556(7699), pp. 113-117, DOI: 10.1038/nature25986.
Article167 days agoThe Immunomodulatory Metabolite Itaconate Modifies NLRP3 and Inhibits Inflammasome Activation
Alexander Hooftman, Stefano Angiari, Svenja Hester, Sarah E. Corcoran, Marah C. Runtsch, Chris Ling, Melanie C. Ruzek, Peter F. Slivka, Anne F. McGettrick, Kathy Banahan, Mark Hughes, Alan D. Irvine, Román Fischer, Luke O'neill (2020). The Immunomodulatory Metabolite Itaconate Modifies NLRP3 and Inhibits Inflammasome Activation. Cell Metabolism, 32(3), pp. 468-478.e7, DOI: 10.1016/j.cmet.2020.07.016.
Article167 days agoMetabolic regulation of <scp>NLRP</scp>3
Mark Hughes, Luke O'neill (2017). Metabolic regulation of <scp>NLRP</scp>3. Immunological Reviews, 281(1), pp. 88-98, DOI: 10.1111/imr.12608.
Article167 days agoCaspase-11 promotes allergic airway inflammation
Zbigniew Zasłona, Ewelina Flis, Mieszko M. Wilk, Richard G. Carroll, Eva M. Pålsson‐McDermott, Mark Hughes, Ciana Diskin, Kathy Banahan, Dylan G. Ryan, Alexander Hooftman, Alicja Misiak, Jay Kearney, Günter Lochnit, Wilhelm Bertrams, Timm Greulich, Bernd Schmeck, Oliver J. McElvaney, Kingston H. G. Mills, Ed C. Lavelle, Małgorzata Wygrecka, Emma M. Creagh, Luke O'neill (2020). Caspase-11 promotes allergic airway inflammation. Nature Communications, 11(1), DOI: 10.1038/s41467-020-14945-2.
Article167 days agoGlutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation
Mark Hughes, Alexander Hooftman, Stefano Angiari, Padmaja Tummala, Zbigniew Zasłona, Marah C. Runtsch, Anne F. McGettrick, Caroline E. Sutton, Ciana Diskin, Melissa Rooke, Shuhei Takahashi, Srinivasan Sundararaj, Marco G. Casarotto, Jane E. Dahlstrom, Eva M. Pålsson‐McDermott, Sinéad C. Corr, Kingston H. G. Mills, Roger J. S. Preston, Nouri Neamati, Yiyue Xie, Jonathan B. Baell, Philip G. Board, Luke O'neill (2019). Glutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation. Cell Reports, 29(1), pp. 151-161.e5, DOI: 10.1016/j.celrep.2019.08.072.
Article167 days ago