Loading publications…
The last 5 uploaded publications
Ras Promotes Growth by Alternative Splicing-Mediated Inactivation of the KLF6 Tumor Suppressor in Hepatocellular Carcinoma
Steven Yea, Goutham Narla, Xiao Zhao, Rakhi Garg, Sigal Tal–Kremer, Eldad A. Hod, Augusto Villanueva, Johnny Loke, Mirko Tarocchi, Kunihara Akita, Senji Shirasawa, Takehiko Sasazuki, John A. Martignetti, Josep M. Llovet, Scott L. Friedman (2008). Ras Promotes Growth by Alternative Splicing-Mediated Inactivation of the KLF6 Tumor Suppressor in Hepatocellular Carcinoma. Gastroenterology, 134(5), pp. 1521-1531, DOI: 10.1053/j.gastro.2008.02.015.
Article145 days agoDownregulation of KLF6 is an early event in hepatocarcinogenesis, and stimulates proliferation while reducing differentiation
Sigal Kremer-Tal, Goutham Narla, Ying‐Bei Chen, Eldad A. Hod, Analisa DiFeo, Steven Yea, Ju‐Seog Lee, Myron Schwartz, Swan N. Thung, Isabel Fiel, Michaela S. Banck, Eran Zimran, Snorri S. Thorgeirsson, Vincenzo Mazzaferro, Jordi Bruix, John A. Martignetti, Josep M. Llovet, Scott L. Friedman (2006). Downregulation of KLF6 is an early event in hepatocarcinogenesis, and stimulates proliferation while reducing differentiation. Journal of Hepatology, 46(4), pp. 645-654, DOI: 10.1016/j.jhep.2006.10.012.
Article145 days agoCarcinogen-induced hepatic tumors in KLF6+/− mice recapitulate aggressive human hepatocellular carcinoma associated with p53 pathway deregulation
Mirko Tarocchi, Rebekka A. Hannivoort, Yujin Hoshida, Ursula E. Lee, Diana Vetter, Goutham Narla, Augusto Villanueva, Moshe Oren, Josep M. Llovet, Scott L. Friedman (2011). Carcinogen-induced hepatic tumors in KLF6+/− mice recapitulate aggressive human hepatocellular carcinoma associated with p53 pathway deregulation. Hepatology, 54(2), pp. 522-531, DOI: 10.1002/hep.24413.
Article145 days agoEnhanced hepatocarcinogenesis in mouse models and human hepatocellular carcinoma by coordinate KLF6 depletion and increased messenger RNA splicing
Diana Vetter, Michal Cohen‐Naftaly, Augusto Villanueva, Youngmin A. Lee, Peri Kocabayoglu, Rebekka A. Hannivoort, Goutham Narla, Josep M. Llovet, Swan N. Thung, Scott L. Friedman (2012). Enhanced hepatocarcinogenesis in mouse models and human hepatocellular carcinoma by coordinate KLF6 depletion and increased messenger RNA splicing. Hepatology, 56(4), pp. 1361-1370, DOI: 10.1002/hep.25810.
Article145 days agoDysregulation of hedgehog pathway signaling in hepatocellular carcinoma
Eric R. Lemmer, Ying‐Bei Chen, Steven Yea, Elisa Wurmbach, Myron Schwartz, Gregory Khitrov, Augusto Villanueva, Goutham Narla, Samuel Waxman, Scott L. Friedman, Josep M. Llovet (2006). Dysregulation of hedgehog pathway signaling in hepatocellular carcinoma. Cancer Research, 66, pp. 630-630
Article145 days ago