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The last 5 uploaded publications
A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases
Rebecca C. Coll, Avril A. B. Robertson, Jae Jin Chae, Sarah Higgins, Raúl Muñoz-Planillo, Marco Inserra, Irina Vetter, Lara S. Dungan, Brian G. Monks, Andrea Stutz, Daniel E. Croker, Mark S. Butler, Moritz Haneklaus, Caroline E. Sutton, Gabriel Núñez, Eicke Latz, Daniel L. Kastner, Kingston H. G. Mills, Seth L. Masters, Kate Schroder, Matthew A. Cooper, Luke O'neill (2015). A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases. Nature Medicine, 21(3), pp. 248-255, DOI: 10.1038/nm.3806.
Article167 days agoActivation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes
Seth L. Masters, Aisling Dunne, Shoba Subramanian, Rebecca L. Hull, Gillian M. Tannahill, Fiona A. Sharp, Christine Becker, Luigi Franchi, Eiji Yoshihara, Zhe Chen, N Mullooly, Lisa A. Mielke, James Harris, Rebecca C. Coll, Kingston H. G. Mills, K. Hun Mok, Philip Newsholme, Gabriel Nuñez, Junji Yodoi, Steven E. Kahn, Ed C. Lavelle, Luke O'neill (2010). Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes. Nature Immunology, 11(10), pp. 897-904, DOI: 10.1038/ni.1935.
Article167 days agoT helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4 <sup>+</sup> T cells
Giuseppina Arbore, Erin E. West, Rosanne Spolski, Avril A. B. Robertson, Andreas Klos, Claudia Rheinheimer, Pavel Dutow, Trent M. Woodruff, Zu Xi Yu, Luke O'neill, Rebecca C. Coll, Alan Sher, Warren J. Leonard, Jörg Köhl, Peter N. Monk, Matthew A. Cooper, Matthew Arno, Behdad Afzali, Helen J. Lachmann, Andrew P. Cope, Katrin D. Mayer-Barber, Claudia Kemper (2016). T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4 <sup>+</sup> T cells. Science, 352(6292), DOI: 10.1126/science.aad1210.
Article167 days agoThe NLRP3 inflammasome functions as a driver of the myelodysplastic syndrome phenotype
Ashley A. Basiorka, Kathy L. McGraw, Erika A. Eksioglu, Xianghong Chen, Joseph Johnson, Ling Zhang, Qing Zhang, Brittany Irvine, Thomas Cluzeau, David A. Sallman, Eric Padron, Rami S. Komrokji, Lubomir Sokol, Rebecca C. Coll, Avril A. B. Robertson, Matthew A. Cooper, John L. Cleveland, Luke O'neill, Sheng Wei, Alan F. List (2016). The NLRP3 inflammasome functions as a driver of the myelodysplastic syndrome phenotype. Blood, 128(25), pp. 2960-2975, DOI: 10.1182/blood-2016-07-730556.
Article167 days agoMonounsaturated Fatty Acid–Enriched High-Fat Diets Impede Adipose NLRP3 Inflammasome–Mediated IL-1β Secretion and Insulin Resistance Despite Obesity
Orla M. Finucane, Claire L. Lyons, Aoife M. Murphy, Clare M. Reynolds, Rut Klinger, Niamh P. Healy, Aoife A. Cooke, Rebecca C. Coll, Liam McAllan, Kanishka N. Nilaweera, M. O'Reilly, Audrey C. Tierney, Melissa J. Morine, Juan F. Alcalá‐Díaz, José López‐Miranda, Darran P. O’Connor, Luke O'neill, Fiona C. McGillicuddy, Helen M. Roche (2015). Monounsaturated Fatty Acid–Enriched High-Fat Diets Impede Adipose NLRP3 Inflammasome–Mediated IL-1β Secretion and Insulin Resistance Despite Obesity. Diabetes, 64(6), pp. 2116-2128, DOI: 10.2337/db14-1098.
Article167 days ago