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The last 5 uploaded publications
The Immunomodulatory Metabolite Itaconate Modifies NLRP3 and Inhibits Inflammasome Activation
Alexander Hooftman, Stefano Angiari, Svenja Hester, Sarah E. Corcoran, Marah C. Runtsch, Chris Ling, Melanie C. Ruzek, Peter F. Slivka, Anne F. McGettrick, Kathy Banahan, Mark Hughes, Alan D. Irvine, Román Fischer, Luke O'neill (2020). The Immunomodulatory Metabolite Itaconate Modifies NLRP3 and Inhibits Inflammasome Activation. Cell Metabolism, 32(3), pp. 468-478.e7, DOI: 10.1016/j.cmet.2020.07.016.
Article167 days agoItaconate and itaconate derivatives target JAK1 to suppress alternative activation of macrophages
Marah C. Runtsch, Stefano Angiari, Alexander Hooftman, Ridhima Wadhwa, Yanling Zhang, Yunan Zheng, Joseph S. Spina, Melanie C. Ruzek, M.A. Argiriadi, Anne F. McGettrick, Rui Santalla Méndez, Alessia Zotta, Christian G. Peace, Aoife Walsh, Roberta Chirillo, Emily Hams, Padraic G. Fallon, Ranjith Jayaraman, Kamal Dua, Alexandra C. Brown, Richard Kim, Jay C. Horvat, Philip M. Hansbro, Chu Wang, Luke O'neill (2022). Itaconate and itaconate derivatives target JAK1 to suppress alternative activation of macrophages. Cell Metabolism, 34(3), pp. 487-501.e8, DOI: 10.1016/j.cmet.2022.02.002.
Article167 days agoThe Immunomodulatory Potential of the Metabolite Itaconate
Alexander Hooftman, Luke O'neill (2019). The Immunomodulatory Potential of the Metabolite Itaconate. Trends in Immunology, 40(8), pp. 687-698, DOI: 10.1016/j.it.2019.05.007.
Article167 days agoMacrophage fumarate hydratase restrains mtRNA-mediated interferon production
Alexander Hooftman, Christian G. Peace, Dylan G. Ryan, Emily A. Day, Ming Yang, Anne F. McGettrick, Maureen Yin, Erica N. Montano, Lihong Huo, Juliana E. Toller-Kawahisa, Vincent Zecchini, Tristram A. J. Ryan, Alfonso Bolado‐Carrancio, Alva M. Casey, Hiran A. Prag, Ana S.H. Costa, Gabriela De Los Santos, Mariko Ishimori, Daniel J. Wallace, Swamy Venuturupalli, Efterpi Nikitopoulou, Norma Frizzell, Cecilia Johansson, Alex von Kriegsheim, Michael P. Murphy, Caroline A. Jefferies, Christian Frezza, Luke O'neill (2023). Macrophage fumarate hydratase restrains mtRNA-mediated interferon production. Nature, 615(7952), pp. 490-498, DOI: 10.1038/s41586-023-05720-6.
Article167 days agoCaspase-11 promotes allergic airway inflammation
Zbigniew Zasłona, Ewelina Flis, Mieszko M. Wilk, Richard G. Carroll, Eva M. Pålsson‐McDermott, Mark Hughes, Ciana Diskin, Kathy Banahan, Dylan G. Ryan, Alexander Hooftman, Alicja Misiak, Jay Kearney, Günter Lochnit, Wilhelm Bertrams, Timm Greulich, Bernd Schmeck, Oliver J. McElvaney, Kingston H. G. Mills, Ed C. Lavelle, Małgorzata Wygrecka, Emma M. Creagh, Luke O'neill (2020). Caspase-11 promotes allergic airway inflammation. Nature Communications, 11(1), DOI: 10.1038/s41467-020-14945-2.
Article167 days ago