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Targeting the ER stress sensor IRE1 protects the liver from fibrosis through the downregulation of the proteostasis factor P4HB/PDIA1
Younis Hazari, Lama Habbouche, Valeria A. Garcia Lopez, Hery Urra, Javier Diaz, Giovanni Tamburini, Mateus Milani, Sylvère Durand, Fanny Aprahamian, Reese Baxter, Menghao Huang, X. Charlie Dong, Luis González-Rojas, Jorge F. Silva, Ignacio Tapia-Dufey, Helena Vihinen, Vlad Ratziu, Fabienne Foufelle, Jan G. Hengstler, Eija Jokitalo, Jessica L. Maiers, Lars Plate, Guido Guido Kroemer, Béatrice Bailly-Maître, Claudio Hetz (2025). Targeting the ER stress sensor IRE1 protects the liver from fibrosis through the downregulation of the proteostasis factor P4HB/PDIA1. , DOI: https://doi.org/10.1097/hep.0000000000001335.
Article73 days agoAuthor Reply to Peer Reviews of Targeting the ER stress sensor IRE1 protects the liver from fibrosis through the downregulation of the proteostasis factor P4HB/PDIA1
Younis Hazari, Hery Urra, Valeria A. Garcia Lopez, Lama Habbouche, Javier Diaz, Giovanni Tamburini, Mateus Milani, Philippe Pihán, Sylvère Durand, Fanny Aprahamian, Reese Baxter, Menghao Huang, Xiulin Dong, Helena Vihinen, Ana Batista Gonzalez, Patrício Godoy, Alfredo Criollo, Vlad Ratziu, Fabienne Foufelle, Jan G. Hengstler, Eija Jokitalo, Jessica L. Maiers, Lars Plate, Guido Guido Kroemer, Béatrice Bailly-Maître, Claudio Hetz (2024). Author Reply to Peer Reviews of Targeting the ER stress sensor IRE1 protects the liver from fibrosis through the downregulation of the proteostasis factor P4HB/PDIA1. , DOI: https://doi.org/10.15252/rc.2024283700.
Preprint73 days agoThe endoplasmic reticulum stress sensor IRE1 regulates collagen secretion through the enforcement of the proteostasis factor P4HB/PDIA1 contributing to liver damage and fibrosis
Younis Hazari, Hery Urra, Valeria A. Garcia Lopez, Javier Diaz, Giovanni Tamburini, Mateus Milani, Philippe Pihán, Sylvère Durand, Fanny Aprahamia, Reese Baxter, Menghao Huang, Xiaonan Dong, Helena Vihinen, Ana Batista-Gonzalez, Patrício Godoy, Alfredo Criollo, Vlad Ratziu, Fabienne Foufelle, Jan G. Hengstler, Eija Jokitalo, Béatrice Bailly-Maître, Jessica L. Maiers, Lars Plate, Guido Guido Kroemer, Claudio Hetz (2023). The endoplasmic reticulum stress sensor IRE1 regulates collagen secretion through the enforcement of the proteostasis factor P4HB/PDIA1 contributing to liver damage and fibrosis. , DOI: https://doi.org/10.1101/2023.05.02.538835.
Preprint73 days agoControl of lysosomal-mediated cell death by the pH-dependent calcium channel RECS1
Philippe Pihán, Fernanda Lisbona, Janina Borgonovo, Sandra Edwards‐Jorquera, Paula Nunes, Karen Castillo, Oliver Kepp, Hery Urra, Suvi Saarnio, Helena Vihinen, Amado Carreras‐Sureda, Sabrina Forveille, Allan Sauvat, Daniela De Giorgis, Amaury Pupo, Diego A. Rodríguez, Giovanni Quarato, Alfredo Sagredo, Fernanda Lourido, Anthony Letai, Ramón Latorre, Guido Guido Kroemer, Nicolas Demaurex, Eija Jokitalo, Miguel L. Concha, Álvaro Glavic, Douglas R. Green, Claudio Hetz (2021). Control of lysosomal-mediated cell death by the pH-dependent calcium channel RECS1. , 7(46), DOI: https://doi.org/10.1126/sciadv.abe5469.
Article73 days agoControl of lysosomal-mediated cell death by the pH-dependent calcium channel RECS1
Philippe Pihán, Fernanda Lisbona, Janina Borgonovo, Sandra Edwards‐Jorquera, Paula Nunes, Karen Castillo, Oliver Kepp, Hery Urra, Suvi Saarnio, Helena Vihinen, Amado Carreras‐Sureda, Sabrina Forveille, Allan Sauvat, Daniela De Giorgis, Amaury Pupo, Diego A. Rodríguez, Giovanni Quarato, Alfredo Sagredo, Fernanda Lourido, Anthony Letai, Ramón Latorre, Guido Guido Kroemer, Nicolas Demaurex, Eija Jokitalo, Miguel L. Concha, Álvaro Glavic, Douglas R. Green, Claudio Hetz (2021). Control of lysosomal-mediated cell death by the pH-dependent calcium channel RECS1. , 7(46), DOI: https://doi.org/10.1126/sciadv.abe5469.
Article73 days ago