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The last 5 uploaded publications
Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages
Evanna L. Mills, Beth Kelly, Angela Logan, Ana S.H. Costa, Mukund Varma, Clare Bryant, Panagiotis Tourlomousis, J. Henry M. Däbritz, Eyal Gottlieb, Isabel Latorre, Sinéad C. Corr, Gavin McManus, Dylan G. Ryan, Howard T. Jacobs, Marten Szibor, Ramnik J. Xavier, Thomas Braun, Christian Frezza, Michael P. Murphy, Luke O'neill (2016). Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages. Cell, 167(2), pp. 457-470.e13, DOI: 10.1016/j.cell.2016.08.064.
Article167 days agoItaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1
Evanna L. Mills, Dylan G. Ryan, Hiran A. Prag, Dina Dikovskaya, Deepthi Menon, Zbigniew Zasłona, Mark P. Jedrychowski, Ana S.H. Costa, Maureen Higgins, Emily Hams, John Szpyt, Marah C. Runtsch, Martin S. King, Joanna F. McGouran, Román Fischer, Benedikt M. Kessler, Anne F. McGettrick, Mark Hughes, Richard G. Carroll, Lee M. Booty, Elena V. Knatko, Paul J. Meakin, Michael L.J. Ashford, Louise K. Modis, Gino Brunori, Daniel C. Sévin, Padraic G. Fallon, Stuart T. Caldwell, Edmund R.S. Kunji, Edward T. Chouchani, Christian Frezza, Albena T. Dinkova‐Kostova, Richard C. Hartley, Michael P. Murphy, Luke O'neill (2018). Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1. Nature, 556(7699), pp. 113-117, DOI: 10.1038/nature25986.
Article167 days agoMitochondria are the powerhouses of immunity
Evanna L. Mills, Beth Kelly, Luke O'neill (2017). Mitochondria are the powerhouses of immunity. Nature Immunology, 18(5), pp. 488-498, DOI: 10.1038/ni.3704.
Article167 days agoSuccinate: a metabolic signal in inflammation
Evanna L. Mills, Luke O'neill (2013). Succinate: a metabolic signal in inflammation. Trends in Cell Biology, 24(5), pp. 313-320, DOI: 10.1016/j.tcb.2013.11.008.
Article167 days agoInhibiting the NLRP3 inflammasome with MCC950 promotes non-phlogistic clearance of amyloid-β and cognitive function in APP/PS1 mice
Colin Dempsey, Ana Rubio‐Araiz, Karen Bryson, Orla M. Finucane, Caroline M. Larkin, Evanna L. Mills, Avril A. B. Robertson, Matthew A. Cooper, Luke O'neill, Marina A. Lynch (2016). Inhibiting the NLRP3 inflammasome with MCC950 promotes non-phlogistic clearance of amyloid-β and cognitive function in APP/PS1 mice. Brain Behavior and Immunity, 61, pp. 306-316, DOI: 10.1016/j.bbi.2016.12.014.
Article167 days ago