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The last 5 uploaded publications
Succinate is an inflammatory signal that induces IL-1β through HIF-1α
Gillian M. Tannahill, Annie M. Curtis, Juraj Adamik, Eva M. Pålsson‐McDermott, Anne F. McGettrick, Gautam Goel, Christian Frezza, Nicholas J. Bernard, Beth Kelly, Niamh H. Foley, Liang Zheng, Agnès Gardet, Zhen Tong, S. S. Jany, Sinéad C. Corr, Moritz Haneklaus, Brian E. Caffrey, Kerry A. Pierce, Sarah R. Walmsley, Federico C. Beasley, Eoin P. Cummins, Victor Nizet, Moira K. B. Whyte, Cormac T. Taylor, Hening Lin, Seth L. Masters, Eyal Gottlieb, Vincent P. Kelly, Clary B. Clish, Philip E. Auron, Ramnik J. Xavier, Luke O'neill (2013). Succinate is an inflammatory signal that induces IL-1β through HIF-1α. Nature, 496(7444), pp. 238-242, DOI: 10.1038/nature11986.
Article167 days agoSuccinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages
Evanna L. Mills, Beth Kelly, Angela Logan, Ana S.H. Costa, Mukund Varma, Clare Bryant, Panagiotis Tourlomousis, J. Henry M. Däbritz, Eyal Gottlieb, Isabel Latorre, Sinéad C. Corr, Gavin McManus, Dylan G. Ryan, Howard T. Jacobs, Marten Szibor, Ramnik J. Xavier, Thomas Braun, Christian Frezza, Michael P. Murphy, Luke O'neill (2016). Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages. Cell, 167(2), pp. 457-470.e13, DOI: 10.1016/j.cell.2016.08.064.
Article167 days agoTLR9 Provokes Inflammation in Response to Fetal DNA: Mechanism for Fetal Loss in Preterm Birth and Preeclampsia
Andrea Scharfe-Nugent, Sinéad C. Corr, Susan Carpenter, Louise Keogh, Brendan Doyle, Cara Martin, Katherine A. Fitzgerald, Sean Daly, John O’Leary, Luke O'neill (2012). TLR9 Provokes Inflammation in Response to Fetal DNA: Mechanism for Fetal Loss in Preterm Birth and Preeclampsia. The Journal of Immunology, 188(11), pp. 5706-5712, DOI: 10.4049/jimmunol.1103454.
Article167 days agoProtective Role for Caspase-11 during Acute Experimental Murine Colitis
Katarzyna Oficjalska, Mathilde Raverdeau, Gabriella Aviello, Siobhan Wade, Ana Hickey, Katherine M. Sheehan, Sinéad C. Corr, Elaine W. Kay, Luke O'neill, Kingston H. G. Mills, Emma M. Creagh (2014). Protective Role for Caspase-11 during Acute Experimental Murine Colitis. The Journal of Immunology, 194(3), pp. 1252-1260, DOI: 10.4049/jimmunol.1400501.
Article167 days agoGlutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation
Mark Hughes, Alexander Hooftman, Stefano Angiari, Padmaja Tummala, Zbigniew Zasłona, Marah C. Runtsch, Anne F. McGettrick, Caroline E. Sutton, Ciana Diskin, Melissa Rooke, Shuhei Takahashi, Srinivasan Sundararaj, Marco G. Casarotto, Jane E. Dahlstrom, Eva M. Pålsson‐McDermott, Sinéad C. Corr, Kingston H. G. Mills, Roger J. S. Preston, Nouri Neamati, Yiyue Xie, Jonathan B. Baell, Philip G. Board, Luke O'neill (2019). Glutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation. Cell Reports, 29(1), pp. 151-161.e5, DOI: 10.1016/j.celrep.2019.08.072.
Article167 days ago