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The last 5 uploaded publications
Succinate is an inflammatory signal that induces IL-1β through HIF-1α
Gillian M. Tannahill, Annie M. Curtis, Juraj Adamik, Eva M. Pålsson‐McDermott, Anne F. McGettrick, Gautam Goel, Christian Frezza, Nicholas J. Bernard, Beth Kelly, Niamh H. Foley, Liang Zheng, Agnès Gardet, Zhen Tong, S. S. Jany, Sinéad C. Corr, Moritz Haneklaus, Brian E. Caffrey, Kerry A. Pierce, Sarah R. Walmsley, Federico C. Beasley, Eoin P. Cummins, Victor Nizet, Moira K. B. Whyte, Cormac T. Taylor, Hening Lin, Seth L. Masters, Eyal Gottlieb, Vincent P. Kelly, Clary B. Clish, Philip E. Auron, Ramnik J. Xavier, Luke O'neill (2013). Succinate is an inflammatory signal that induces IL-1β through HIF-1α. Nature, 496(7444), pp. 238-242, DOI: 10.1038/nature11986.
Article167 days agoA small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases
Rebecca C. Coll, Avril A. B. Robertson, Jae Jin Chae, Sarah Higgins, Raúl Muñoz-Planillo, Marco Inserra, Irina Vetter, Lara S. Dungan, Brian G. Monks, Andrea Stutz, Daniel E. Croker, Mark S. Butler, Moritz Haneklaus, Caroline E. Sutton, Gabriel Núñez, Eicke Latz, Daniel L. Kastner, Kingston H. G. Mills, Seth L. Masters, Kate Schroder, Matthew A. Cooper, Luke O'neill (2015). A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases. Nature Medicine, 21(3), pp. 248-255, DOI: 10.1038/nm.3806.
Article167 days agoActivation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes
Seth L. Masters, Aisling Dunne, Shoba Subramanian, Rebecca L. Hull, Gillian M. Tannahill, Fiona A. Sharp, Christine Becker, Luigi Franchi, Eiji Yoshihara, Zhe Chen, N Mullooly, Lisa A. Mielke, James Harris, Rebecca C. Coll, Kingston H. G. Mills, K. Hun Mok, Philip Newsholme, Gabriel Nuñez, Junji Yodoi, Steven E. Kahn, Ed C. Lavelle, Luke O'neill (2010). Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes. Nature Immunology, 11(10), pp. 897-904, DOI: 10.1038/ni.1935.
Article167 days agoCutting Edge: miR-223 and EBV miR-BART15 Regulate the NLRP3 Inflammasome and IL-1β Production
Moritz Haneklaus, Motti Gerlic, Mariola Kurowska‐Stolarska, A. Rainey, Dagmar Pich, Iain B. McInnes, Wolfgang Hammerschmidt, Luke O'neill, Seth L. Masters (2012). Cutting Edge: miR-223 and EBV miR-BART15 Regulate the NLRP3 Inflammasome and IL-1β Production. The Journal of Immunology, 189(8), pp. 3795-3799, DOI: 10.4049/jimmunol.1200312.
Article167 days agomiR‐223: infection, inflammation and cancer
Moritz Haneklaus, Motti Gerlic, Luke O'neill, Seth L. Masters (2013). miR‐223: infection, inflammation and cancer. Journal of Internal Medicine, 274(3), pp. 215-226, DOI: 10.1111/joim.12099.
Article167 days ago