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The last 5 uploaded publications
Gut microbiota modulation through Akkermansia spp. supplementation increases CAR-T cell potency
Laura Marcos-Kovandzic, Michele Avagliano, Myriam Ben Khelil, Janesa Srikanthan, Rim ABDALLAH, Valentina Petrocelli, Jessica Rengassamy, Alexia Alfaro, Mathilde Bied, Marine Fidelle, Gladys Ferrere, Romain Daillère, Ahmadreza Arbab, Roula Amine-Hneineh, Arnaud Pagès, Peggy Dartigues, Pierre Ly, Sylvain Simon, Sylvère Durand, Adrian Gottschlich, Florent Ginhoux, Camille Blériot, Peng Liu, Liwei Zhao, Laura Creusot, Nathalie Rolhion, Guido Kroemer, Laurie Menger, Sebastian Kobold, Cristina Castilla‐Llorente, Harry Sokol, Stefano Casola, Edoardo Pasolli, Laurence Zitvogel, Camille Bigenwald (2025). Gut microbiota modulation through Akkermansia spp. supplementation increases CAR-T cell potency. , DOI: https://doi.org/10.1158/2159-8290.cd-24-1230.
Article74 days agoAutophagy is required for the therapeutic effects of the NAD+ precursor nicotinamide in obesity-related heart failure with preserved ejection fraction
Mahmoud Abdellatif, Francisco Vasques‐Nóvoa, Viktoria Trummer-Herbst, Sylvère Durand, Franziska Koser, Moydul Islam, Jihoon Nah, Eun‐Ah Sung, Ruli Feng, Fanny Aprahamian, Andreas Prokesch, Andreas Prokesch, Junichi Sadoshima, Abhinav Diwan, Wolfgang A. Linke, João Pedro Ferreira, Guido Guido Kroemer, Simon Sedej (2025). Autophagy is required for the therapeutic effects of the NAD+ precursor nicotinamide in obesity-related heart failure with preserved ejection fraction. , DOI: https://doi.org/10.1093/eurheartj/ehaf062.
Article73 days agoTargeting the ER stress sensor IRE1 protects the liver from fibrosis through the downregulation of the proteostasis factor P4HB/PDIA1
Younis Hazari, Lama Habbouche, Valeria A. Garcia Lopez, Hery Urra, Javier Diaz, Giovanni Tamburini, Mateus Milani, Sylvère Durand, Fanny Aprahamian, Reese Baxter, Menghao Huang, X. Charlie Dong, Luis González-Rojas, Jorge F. Silva, Ignacio Tapia-Dufey, Helena Vihinen, Vlad Ratziu, Fabienne Foufelle, Jan G. Hengstler, Eija Jokitalo, Jessica L. Maiers, Lars Plate, Guido Guido Kroemer, Béatrice Bailly-Maître, Claudio Hetz (2025). Targeting the ER stress sensor IRE1 protects the liver from fibrosis through the downregulation of the proteostasis factor P4HB/PDIA1. , DOI: https://doi.org/10.1097/hep.0000000000001335.
Article73 days agoAbstract 2210: Microbiome profiling reveals that fecal microbiota transplantation (FMT) modulates response and toxicity when combined with immunotherapy in patients with lung cancer and melanoma (FMT-LUMINate NCT04951583)
Sreya Duttagupta, Meriem Messaoudene, Rahima Jamal, Catalin Mihalcioiu, Nicolas Marcoux, Sebastian Hunter, Gianmarco Piccinno, Michal Punčochář, Karl Bélanger, Mustapha Tehfé, Normand Blais, Scott Owen, Jacques Raphael, Jade Maillou, Yongjia Hu, Myriam Benlaïfaoui, Somayeh Nilli, John Lenehan, Wiam Belkaïd, Seema Nair Parvathy, Diogjena Katerina Prifti, Marine Fidelle, Seunghee Kim‐Schulze, Thomas U. Marron, Sylvère Durand, Guido Guido Kroemer, Nicola Segata, Lisa Derosa, Laurence Zitvogel, Antoine Desîlets, Michael E. Silverman, Saman MalekiVareki, Bertrand Routy, Arielle Elkrief (2025). Abstract 2210: Microbiome profiling reveals that fecal microbiota transplantation (FMT) modulates response and toxicity when combined with immunotherapy in patients with lung cancer and melanoma (FMT-LUMINate NCT04951583). , 85(8_Supplement_1), DOI: https://doi.org/10.1158/1538-7445.am2025-2210.
Article73 days agoNeutralization of acyl coenzyme A binding protein for the experimental prevention and treatment of hepatocellular carcinoma
Sylvie Lachkar, Ester Gloria Saavedra Díaz, Li Sun, Chantal Desdouets, Sabine Colnot, Oliver Kepp, Isabelle Martins, Laurence Zitvogel, Mauro Piacentini, Jean‐Charles Nault, Maria Chiara Maiuri, Jessica Zucman‐Rossi, Guido Guido Kroemer, Sijing Li, Omar Motiño, Flavia Lambertucci, Jonathan Pol, Hui Chen, Long Pan, Sylvère Durand, Federica Rossin, Claudia Campani, Lucie Poupel, Christophe Klein, Léa Montégut, María Pérez-Lanzón, Gerasimos Anagnostopoulos, Uxía Nogueira-Recalde, Alexandra Cerone, Fanny Aprahamian, Yanbing Dong, Manuela Lizarralde-Guerrero, Enfu Xue, Peng Liu, Liwei Zhao, Hui Pan, Vincent Carbonnier (2025). Neutralization of acyl coenzyme A binding protein for the experimental prevention and treatment of hepatocellular carcinoma. , 6(7), DOI: https://doi.org/10.1016/j.xcrm.2025.102232.
Article73 days ago