Loading publications…
The last 5 uploaded publications
Succinate is an inflammatory signal that induces IL-1β through HIF-1α
Gillian M. Tannahill, Annie M. Curtis, Juraj Adamik, Eva M. Pålsson‐McDermott, Anne F. McGettrick, Gautam Goel, Christian Frezza, Nicholas J. Bernard, Beth Kelly, Niamh H. Foley, Liang Zheng, Agnès Gardet, Zhen Tong, S. S. Jany, Sinéad C. Corr, Moritz Haneklaus, Brian E. Caffrey, Kerry A. Pierce, Sarah R. Walmsley, Federico C. Beasley, Eoin P. Cummins, Victor Nizet, Moira K. B. Whyte, Cormac T. Taylor, Hening Lin, Seth L. Masters, Eyal Gottlieb, Vincent P. Kelly, Clary B. Clish, Philip E. Auron, Ramnik J. Xavier, Luke O'neill (2013). Succinate is an inflammatory signal that induces IL-1β through HIF-1α. Nature, 496(7444), pp. 238-242, DOI: 10.1038/nature11986.
Article167 days agoSuccinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages
Evanna L. Mills, Beth Kelly, Angela Logan, Ana S.H. Costa, Mukund Varma, Clare Bryant, Panagiotis Tourlomousis, J. Henry M. Däbritz, Eyal Gottlieb, Isabel Latorre, Sinéad C. Corr, Gavin McManus, Dylan G. Ryan, Howard T. Jacobs, Marten Szibor, Ramnik J. Xavier, Thomas Braun, Christian Frezza, Michael P. Murphy, Luke O'neill (2016). Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages. Cell, 167(2), pp. 457-470.e13, DOI: 10.1016/j.cell.2016.08.064.
Article167 days agoMetabolic reprogramming in macrophages and dendritic cells in innate immunity
Beth Kelly, Luke O'neill (2015). Metabolic reprogramming in macrophages and dendritic cells in innate immunity. Cell Research, 25(7), pp. 771-784, DOI: 10.1038/cr.2015.68.
Article167 days agoMitochondria are the powerhouses of immunity
Evanna L. Mills, Beth Kelly, Luke O'neill (2017). Mitochondria are the powerhouses of immunity. Nature Immunology, 18(5), pp. 488-498, DOI: 10.1038/ni.3704.
Article167 days agoMetformin Inhibits the Production of Reactive Oxygen Species from NADH:Ubiquinone Oxidoreductase to Limit Induction of Interleukin-1β (IL-1β) and Boosts Interleukin-10 (IL-10) in Lipopolysaccharide (LPS)-activated Macrophages
Beth Kelly, Gillian M. Tannahill, Michael P. Murphy, Luke O'neill (2015). Metformin Inhibits the Production of Reactive Oxygen Species from NADH:Ubiquinone Oxidoreductase to Limit Induction of Interleukin-1β (IL-1β) and Boosts Interleukin-10 (IL-10) in Lipopolysaccharide (LPS)-activated Macrophages. Journal of Biological Chemistry, 290(33), pp. 20348-20359, DOI: 10.1074/jbc.m115.662114.
Article167 days ago