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The last 5 uploaded publications
Succinate is an inflammatory signal that induces IL-1β through HIF-1α
Gillian M. Tannahill, Annie M. Curtis, Juraj Adamik, Eva M. Pålsson‐McDermott, Anne F. McGettrick, Gautam Goel, Christian Frezza, Nicholas J. Bernard, Beth Kelly, Niamh H. Foley, Liang Zheng, Agnès Gardet, Zhen Tong, S. S. Jany, Sinéad C. Corr, Moritz Haneklaus, Brian E. Caffrey, Kerry A. Pierce, Sarah R. Walmsley, Federico C. Beasley, Eoin P. Cummins, Victor Nizet, Moira K. B. Whyte, Cormac T. Taylor, Hening Lin, Seth L. Masters, Eyal Gottlieb, Vincent P. Kelly, Clary B. Clish, Philip E. Auron, Ramnik J. Xavier, Luke O'neill (2013). Succinate is an inflammatory signal that induces IL-1β through HIF-1α. Nature, 496(7444), pp. 238-242, DOI: 10.1038/nature11986.
Article167 days agoPyruvate Kinase M2 Regulates Hif-1α Activity and IL-1β Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages
Eva M. Pålsson‐McDermott, Annie M. Curtis, Gautam Goel, Mario A. Lauterbach, Frederick J. Sheedy, Laura E. Gleeson, Mirjam W.M. van den Bosch, Susan R. Quinn, Raquel Domingo-Fernandéz, Daniel Johnston, Jian‐kang Jiang, William J. Israelsen, Joseph Keane, Craig J. Thomas, Clary B. Clish, Matthew G. Vander Heiden, Ramnik J. Xavier, Luke O'neill (2015). Pyruvate Kinase M2 Regulates Hif-1α Activity and IL-1β Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages. Cell Metabolism, 21(1), pp. 65-80, DOI: 10.1016/j.cmet.2014.12.005.
Article167 days agoCircadian Clock Proteins and Immunity
Annie M. Curtis, Marina Maria Bellet, Paolo Sassone–Corsi, Luke O'neill (2014). Circadian Clock Proteins and Immunity. Immunity, 40(2), pp. 178-186, DOI: 10.1016/j.immuni.2014.02.002.
Article167 days agoCircadian clock protein BMAL1 regulates IL-1β in macrophages via NRF2
James O. Early, Deepthi Menon, Cathy Wyse, Mariana P. Cervantes‐Silva, Zbigniew Zasłona, Richard G. Carroll, Eva M. Pålsson‐McDermott, Stefano Angiari, Dylan G. Ryan, Sarah E. Corcoran, George A. Timmons, Sarah S. Geiger, Darren J. Fitzpatrick, Daniel J. O’Connell, Ramnik J. Xavier, Karsten Hokamp, Luke O'neill, Annie M. Curtis (2018). Circadian clock protein BMAL1 regulates IL-1β in macrophages via NRF2. Proceedings of the National Academy of Sciences, 115(36), DOI: 10.1073/pnas.1800431115.
Article167 days agoCircadian control of innate immunity in macrophages by miR-155 targeting <i>Bmal1</i>
Annie M. Curtis, Caio T. Fagundes, Guangrui Yang, Eva M. Pålsson‐McDermott, Paulina Wochal, Anne F. McGettrick, Niamh H. Foley, James O. Early, Lihong Chen, Hanrui Zhang, Chenyi Xue, Sarah S. Geiger, Karsten Hokamp, Muredach P. Reilly, Andrew N. Coogan, Elena Vigorito, Garret A. FitzGerald, Luke O'neill (2015). Circadian control of innate immunity in macrophages by miR-155 targeting <i>Bmal1</i>. Proceedings of the National Academy of Sciences, 112(23), pp. 7231-7236, DOI: 10.1073/pnas.1501327112.
Article167 days ago