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Autophagy is required for the therapeutic effects of the NAD+ precursor nicotinamide in obesity-related heart failure with preserved ejection fraction
Mahmoud Abdellatif, Francisco Vasques‐Nóvoa, Viktoria Trummer-Herbst, Sylvère Durand, Franziska Koser, Moydul Islam, Jihoon Nah, Eun‐Ah Sung, Ruli Feng, Fanny Aprahamian, Andreas Prokesch, Andreas Prokesch, Junichi Sadoshima, Abhinav Diwan, Wolfgang A. Linke, João Pedro Ferreira, Guido Guido Kroemer, Simon Sedej (2025). Autophagy is required for the therapeutic effects of the NAD+ precursor nicotinamide in obesity-related heart failure with preserved ejection fraction. , DOI: https://doi.org/10.1093/eurheartj/ehaf062.
Article73 days agoACBP/DBI protein neutralization confers autophagy-dependent organ protection through inhibition of cell loss, inflammation, and fibrosis
Omar Motiño, Flavia Lambertucci, Gerasimos Anagnostopoulos, Sijing Li, Jihoon Nah, Francesca Castoldi, Laura Senovilla, Léa Montégut, Hui Chen, Sylvère Durand, Mélanie Bourgin, Fanny Aprahamian, Nitharsshini Nirmalathasan, Karla Alvarez-Valadez, Allan Sauvat, Vincent Carbonnier, Mojgan Djavaheri‐Mergny, Federico Pietrocola, Junichi Sadoshima, Maria Chiara Maiuri, Isabelle Martins, Guido Guido Kroemer (2022). ACBP/DBI protein neutralization confers autophagy-dependent organ protection through inhibition of cell loss, inflammation, and fibrosis. , 119(41), DOI: https://doi.org/10.1073/pnas.2207344119.
Article73 days agoThe flavonoid 4,4′-dimethoxychalcone promotes autophagy-dependent longevity across species
Didac Carmona‐Gutiérrez, Andreas Zimmermann, Katharina Kainz, Federico Pietrocola, Guo Chen, Silvia Maglioni, Alfonso Schiavi, Jihoon Nah, Sara Mertel, Christine B. Beuschel, Francesca Castoldi, Valentina Sica, Gert Trausinger, Reingard Raml, Cornelia Sommer, Sabrina Schroeder, Sebastian J. Hofer, Maria A. Bauer, Tobias Pendl, Jelena Tadić, Christopher Dammbrueck, Zehan Hu, Christoph Ruckenstuhl, Tobias Eisenberg, Sylvère Durand, Noélie Bossut, Fanny Aprahamian, Mahmoud Abdellatif, Simon Sedej, David Enot, Heimo Wolinski, Jörn Dengjel, Oliver Kepp, Christoph Magnes, Frank Sinner, Thomas R. Pieber, Junichi Sadoshima, Natascia Ventura, Stephan J. Sigrist, Guido Guido Kroemer, Frank Madeo (2019). The flavonoid 4,4′-dimethoxychalcone promotes autophagy-dependent longevity across species. , 10(1), DOI: https://doi.org/10.1038/s41467-019-08555-w.
Article73 days ago3,4‐Dimethoxychalcone induces autophagy through activation of the transcription factors <scp>TFE</scp> 3 and <scp>TFEB</scp>
Guo Chen, Wei Xie, Jihoon Nah, Allan Sauvat, Peng Liu, Federico Pietrocola, Valentina Sica, Didac Carmona‐Gutiérrez, Andreas Zimmermann, Tobias Pendl, Jelena Tadić, Martina Bergmann, Sebastian J. Hofer, Lana Domuz, Sylvie Lachkar, Maria Markaki, Nektarios Tavernarakis, Junichi Sadoshima, Frank Madeo, Oliver Kepp, Guido Guido Kroemer (2019). 3,4‐Dimethoxychalcone induces autophagy through activation of the transcription factors <scp>TFE</scp> 3 and <scp>TFEB</scp>. , 11(11), DOI: https://doi.org/10.15252/emmm.201910469.
Article73 days ago