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The last 5 uploaded publications
Itaconate and itaconate derivatives target JAK1 to suppress alternative activation of macrophages
Marah C. Runtsch, Stefano Angiari, Alexander Hooftman, Ridhima Wadhwa, Yanling Zhang, Yunan Zheng, Joseph S. Spina, Melanie C. Ruzek, M.A. Argiriadi, Anne F. McGettrick, Rui Santalla Méndez, Alessia Zotta, Christian G. Peace, Aoife Walsh, Roberta Chirillo, Emily Hams, Padraic G. Fallon, Ranjith Jayaraman, Kamal Dua, Alexandra C. Brown, Richard Kim, Jay C. Horvat, Philip M. Hansbro, Chu Wang, Luke O'neill (2022). Itaconate and itaconate derivatives target JAK1 to suppress alternative activation of macrophages. Cell Metabolism, 34(3), pp. 487-501.e8, DOI: 10.1016/j.cmet.2022.02.002.
Article167 days agoDimethyl fumarate and 4-octyl itaconate are anticoagulants that suppress Tissue Factor in macrophages via inhibition of Type I Interferon
Tristram A. J. Ryan, Alexander Hooftman, Aisling M. Rehill, Matt D. Johansen, Eóin C. O’ Brien, Juliana E. Toller-Kawahisa, Mieszko M. Wilk, Emily A. Day, Hauke J. Weiss, Pourya Sarvari, Emilio G. Vozza, Fabian Schramm, Christian G. Peace, Alessia Zotta, Stefan Miemczyk, Christina Nalkurthi, Nicole G. Hansbro, Gavin McManus, Laura O’Doherty, Siobhán Gargan, Aideen Long, Jean Dunne, Clíona Ní Cheallaigh, Niall Conlon, Michael Carty, Padraic G. Fallon, Kingston H. G. Mills, Emma M. Creagh, James S. O’ Donnell, Paul J. Hertzog, Philip M. Hansbro, Rachel M. McLoughlin, Małgorzata Wygrecka, Roger J. S. Preston, Zbigniew Zasłona, Luke O'neill (2023). Dimethyl fumarate and 4-octyl itaconate are anticoagulants that suppress Tissue Factor in macrophages via inhibition of Type I Interferon. Nature Communications, 14(1), DOI: 10.1038/s41467-023-39174-1.
Article167 days agoUnlocking potential: the role of the electron transport chain in immunometabolism
Alessia Zotta, Luke O'neill, Maureen Yin (2024). Unlocking potential: the role of the electron transport chain in immunometabolism. Trends in Immunology, 45(4), pp. 259-273, DOI: 10.1016/j.it.2024.02.002.
Article167 days agoThe metabolic function of pyruvate kinase M2 regulates reactive oxygen species production and microbial killing by neutrophils
Juliana E. Toller-Kawahisa, Carlos Hiroji Hiroki, Camila M. Silva, Daniele C. Nascimento, Gabriel Azevedo Públio, Timna Varela Martins, Luis Eduardo Alves Damasceno, Flávio P. Veras, Paula Ramos Viacava, Fábio Yuji Sukesada, Emily A. Day, Alessia Zotta, Tristram A. J. Ryan, Rodrigo Moreira da Silva, Thiago M. Cunha, Norberto Peporine Lopes, Fernando Q. Cunha, Luke O'neill, José C. Alves‐Filho (2023). The metabolic function of pyruvate kinase M2 regulates reactive oxygen species production and microbial killing by neutrophils. Nature Communications, 14(1), DOI: 10.1038/s41467-023-40021-6.
Article167 days agoMetabolic reprogramming of macrophages by PKM2 promotes IL-10 production via adenosine
Juliana E. Toller-Kawahisa, Paula Ramos Viacava, Eva M. Pålsson‐McDermott, Daniele C. Nascimento, Mariana P. Cervantes‐Silva, Shane M. O’Carroll, Alessia Zotta, Luis Eduardo Alves Damasceno, Gabriel Azevedo Públio, Pedro Forti, João Paulo Mesquita Luiz, Bruno Marcel Silva de Melo, Timna Varela Martins, Vítor M. Faça, Annie M. Curtis, Thiago M. Cunha, Fernando Q. Cunha, Luke O'neill, José C. Alves‐Filho (2025). Metabolic reprogramming of macrophages by PKM2 promotes IL-10 production via adenosine. Cell Reports, 44(1), pp. 115172-115172, DOI: 10.1016/j.celrep.2024.115172.
Article167 days ago