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The last 5 uploaded publications
A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases
Rebecca C. Coll, Avril A. B. Robertson, Jae Jin Chae, Sarah Higgins, Raúl Muñoz-Planillo, Marco Inserra, Irina Vetter, Lara S. Dungan, Brian G. Monks, Andrea Stutz, Daniel E. Croker, Mark S. Butler, Moritz Haneklaus, Caroline E. Sutton, Gabriel Núñez, Eicke Latz, Daniel L. Kastner, Kingston H. G. Mills, Seth L. Masters, Kate Schroder, Matthew A. Cooper, Luke O'neill (2015). A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases. Nature Medicine, 21(3), pp. 248-255, DOI: 10.1038/nm.3806.
Article167 days agoInflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice
Richard D. Gordon, Eduardo A. Albornoz, Daniel C. Christie, Monica R. Langley, Vinod Kumar, Susanna Mantovani, Avril A. B. Robertson, Mark S. Butler, Dominic B. Rowe, Luke O'neill, Anumantha G. Kanthasamy, Kate Schroder, Matthew A. Cooper, Trent M. Woodruff (2018). Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice. Science Translational Medicine, 10(465), DOI: 10.1126/scitranslmed.aah4066.
Article167 days agoInhibiting the NLRP3 inflammasome with MCC950 promotes non-phlogistic clearance of amyloid-β and cognitive function in APP/PS1 mice
Colin Dempsey, Ana Rubio‐Araiz, Karen Bryson, Orla M. Finucane, Caroline M. Larkin, Evanna L. Mills, Avril A. B. Robertson, Matthew A. Cooper, Luke O'neill, Marina A. Lynch (2016). Inhibiting the NLRP3 inflammasome with MCC950 promotes non-phlogistic clearance of amyloid-β and cognitive function in APP/PS1 mice. Brain Behavior and Immunity, 61, pp. 306-316, DOI: 10.1016/j.bbi.2016.12.014.
Article167 days agoT helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4 <sup>+</sup> T cells
Giuseppina Arbore, Erin E. West, Rosanne Spolski, Avril A. B. Robertson, Andreas Klos, Claudia Rheinheimer, Pavel Dutow, Trent M. Woodruff, Zu Xi Yu, Luke O'neill, Rebecca C. Coll, Alan Sher, Warren J. Leonard, Jörg Köhl, Peter N. Monk, Matthew A. Cooper, Matthew Arno, Behdad Afzali, Helen J. Lachmann, Andrew P. Cope, Katrin D. Mayer-Barber, Claudia Kemper (2016). T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4 <sup>+</sup> T cells. Science, 352(6292), DOI: 10.1126/science.aad1210.
Article167 days agoRole for NLRP3 Inflammasome–mediated, IL-1β–Dependent Responses in Severe, Steroid-Resistant Asthma
Richard Kim, James Pinkerton, Ama‐Tawiah Essilfie, Avril A. B. Robertson, Katherine J. Baines, Alexandra C. Brown, Jemma Mayall, Md Khadem Ali, Malcolm R. Starkey, Nicole G. Hansbro, Jeremy A. Hirota, Lisa G. Wood, Jodie L. Simpson, Darryl A. Knight, Peter Wark, Peter G. Gibson, Luke O'neill, Matthew A. Cooper, Jay C. Horvat, Philip M. Hansbro (2017). Role for NLRP3 Inflammasome–mediated, IL-1β–Dependent Responses in Severe, Steroid-Resistant Asthma. American Journal of Respiratory and Critical Care Medicine, 196(3), pp. 283-297, DOI: 10.1164/rccm.201609-1830oc.
Article167 days ago