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Abstract 2210: Microbiome profiling reveals that fecal microbiota transplantation (FMT) modulates response and toxicity when combined with immunotherapy in patients with lung cancer and melanoma (FMT-LUMINate NCT04951583)
Sreya Duttagupta, Meriem Messaoudene, Rahima Jamal, Catalin Mihalcioiu, Nicolas Marcoux, Sebastian Hunter, Gianmarco Piccinno, Michal Punčochář, Karl Bélanger, Mustapha Tehfé, Normand Blais, Scott Owen, Jacques Raphael, Jade Maillou, Yongjia Hu, Myriam Benlaïfaoui, Somayeh Nilli, John Lenehan, Wiam Belkaïd, Seema Nair Parvathy, Diogjena Katerina Prifti, Marine Fidelle, Seunghee Kim‐Schulze, Thomas U. Marron, Sylvère Durand, Guido Guido Kroemer, Nicola Segata, Lisa Derosa, Laurence Zitvogel, Antoine Desîlets, Michael E. Silverman, Saman MalekiVareki, Bertrand Routy, Arielle Elkrief (2025). Abstract 2210: Microbiome profiling reveals that fecal microbiota transplantation (FMT) modulates response and toxicity when combined with immunotherapy in patients with lung cancer and melanoma (FMT-LUMINate NCT04951583). , 85(8_Supplement_1), DOI: https://doi.org/10.1158/1538-7445.am2025-2210.
Article73 days agoLow-dose irradiation of the gut improves the efficacy of PD-L1 blockade in metastatic cancer patients
Jianzhou Chen, Antonin Lévy, Ai-Ling Tian, Xuehan Huang, Guoxin Cai, Marine Fidelle, Conrad Rauber, Pierre Ly, Eugénie Pizzato, Lisa Sitterlé, Gianmarco Piccinno, Peng Liu, Sylvère Durand, Misha Mao, Liwei Zhao, Valerio Iebba, Hannah Felchle, Anne-Laure Mallard de La Varende, Julius C. Fischer, Simon Thomas, Tim F. Greten, Jennifer Jones, Cecilia Monge, Sandra Demaria, Silvia C. Formenti, Lorenzo Belluomini, V. Dionisi, Christophe Massard, Pierre‐Yves Blanchard, Charlotte Robert, Clément Quevrin, Eloise Lopes, Céline Clémenson, Michele Mondini, Lydia Meziani, Yizhou Zhan, Chengbing Zeng, Qingxin Cai, Daphné Morel, Roger Sun, Pierre-Antoine Laurent, Monica Mangoni, Vanessa Di Cataldo, C. Arilli, Maike Trommer, Simone Wegen, Sebastian Neppl, Rachel P. Riechelmann, Marcos Pedro Guedes Camandaroba, Elson Santos Neto, Pierre‐Edouard Fournier, Nicola Segata, Peter Holíček, Lorenzo Galluzzi, Aitziber Buqué, Carolina Alves Costa Silva, Lisa Derosa, Guido Guido Kroemer, Chuangzhen Chen, Laurence Zitvogel, Éric Deutsch (2025). Low-dose irradiation of the gut improves the efficacy of PD-L1 blockade in metastatic cancer patients. , 43(3), DOI: https://doi.org/10.1016/j.ccell.2025.02.010.
Article73 days agoCustom scoring based on ecological topology of gut microbiota associated with cancer immunotherapy outcome
Lisa Derosa, Valerio Iebba, Carolina Alves Costa Silva, Gianmarco Piccinno, Guojun Wu, Leonardo Lordello, Bertrand Routy, Naisi Zhao, Cassandra Thélémaque, Roxanne Birebent, Federica Marmorino, Marine Fidelle, Meriem Messaoudene, Andrew Maltez Thomas, Gérard Zalcman, S. Friard, Julien Mazières, Clarisse Audigier-Valette, Denis Moro‐Sibilot, François Goldwasser, Arnaud Scherpereel, Hervé Pegliasco, François Ghiringhelli, Nicole Bouchard, Cissé Sow, Ines Darik, Silvia Zoppi, Pierre Ly, Anna Reni, Romain Daillère, Éric Deutsch, Karla A. Lee, Laura A. Bolte, Johannes R. Björk, Rinse K. Weersma, Fabrice Barlési, Lucas Padilha, Ana Finzel, Morten L. Isaksen, Bernard Escudier, Laurence Albigès, David Planchard, Fabrice André, Chiara Cremolini, Stéphanie Martinez, Benjamin Besse, Liping Zhao, Nicola Segata, Jérôme Wojcik, Guido Guido Kroemer, Laurence Zitvogel (2024). Custom scoring based on ecological topology of gut microbiota associated with cancer immunotherapy outcome. , 187(13), DOI: https://doi.org/10.1016/j.cell.2024.05.029.
Article73 days agoInfluence of microbiota-associated metabolic reprogramming on clinical outcome in patients with melanoma from the randomized adjuvant dendritic cell-based MIND-DC trial
Carolina Alves Costa Silva, Gianmarco Piccinno, Déborah Suissa, Mélanie Bourgin, Gerty Schreibelt, Sylvère Durand, Roxanne Birebent, Marine Fidelle, Cissé Sow, Fanny Aprahamian, Paolo Manghi, Michal Punčochář, Francesco Asnicar, Federica Pinto, Federica Armanini, Safae Terrisse, Bertrand Routy, Damien Drubay, Alexander Eggermont, Guido Guido Kroemer, Nicola Segata, Laurence Zitvogel, Lisa Derosa, Kalijn F. Bol, I. Jolanda M. de Vries (2024). Influence of microbiota-associated metabolic reprogramming on clinical outcome in patients with melanoma from the randomized adjuvant dendritic cell-based MIND-DC trial. , 15(1), DOI: https://doi.org/10.1038/s41467-024-45357-1.
Article73 days agoMicrobiota-associated metabolic reprograming influenced clinical outcome in the randomized dendritic cell-based clinical trial in stage III melanoma
Carolina Alves Costa Silva, Mélanie Bourgin, Gianmarco Piccinno, Gerty Schreibelt, Sylvère Durand, Marine Fidelle, Cissé Sow, Roxanne Birebent, Fanny Aprahamian, Paolo Manghi, Francesco Asnicar, Federica Pinto, Federica Armanini, Safae Terrisse, Bertrand Routy, Alexander Eggermont, Guido Guido Kroemer, Nicola Segata, Lisa Derosa, Kalijn F. Bol, I. Jolanda M. de Vries, Laurence Zitvogel (2023). Microbiota-associated metabolic reprograming influenced clinical outcome in the randomized dendritic cell-based clinical trial in stage III melanoma. , DOI: https://doi.org/10.21203/rs.3.rs-2924093/v1.
Preprint73 days ago