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The last 5 uploaded publications
Macrophage fumarate hydratase restrains mtRNA-mediated interferon production
Alexander Hooftman, Christian G. Peace, Dylan G. Ryan, Emily A. Day, Ming Yang, Anne F. McGettrick, Maureen Yin, Erica N. Montano, Lihong Huo, Juliana E. Toller-Kawahisa, Vincent Zecchini, Tristram A. J. Ryan, Alfonso Bolado‐Carrancio, Alva M. Casey, Hiran A. Prag, Ana S.H. Costa, Gabriela De Los Santos, Mariko Ishimori, Daniel J. Wallace, Swamy Venuturupalli, Efterpi Nikitopoulou, Norma Frizzell, Cecilia Johansson, Alex von Kriegsheim, Michael P. Murphy, Caroline A. Jefferies, Christian Frezza, Luke O'neill (2023). Macrophage fumarate hydratase restrains mtRNA-mediated interferon production. Nature, 615(7952), pp. 490-498, DOI: 10.1038/s41586-023-05720-6.
Article167 days agoDimethyl fumarate and 4-octyl itaconate are anticoagulants that suppress Tissue Factor in macrophages via inhibition of Type I Interferon
Tristram A. J. Ryan, Alexander Hooftman, Aisling M. Rehill, Matt D. Johansen, Eóin C. O’ Brien, Juliana E. Toller-Kawahisa, Mieszko M. Wilk, Emily A. Day, Hauke J. Weiss, Pourya Sarvari, Emilio G. Vozza, Fabian Schramm, Christian G. Peace, Alessia Zotta, Stefan Miemczyk, Christina Nalkurthi, Nicole G. Hansbro, Gavin McManus, Laura O’Doherty, Siobhán Gargan, Aideen Long, Jean Dunne, Clíona Ní Cheallaigh, Niall Conlon, Michael Carty, Padraic G. Fallon, Kingston H. G. Mills, Emma M. Creagh, James S. O’ Donnell, Paul J. Hertzog, Philip M. Hansbro, Rachel M. McLoughlin, Małgorzata Wygrecka, Roger J. S. Preston, Zbigniew Zasłona, Luke O'neill (2023). Dimethyl fumarate and 4-octyl itaconate are anticoagulants that suppress Tissue Factor in macrophages via inhibition of Type I Interferon. Nature Communications, 14(1), DOI: 10.1038/s41467-023-39174-1.
Article167 days agoHow neutrophil metabolism affects bacterial killing
Juliana E. Toller-Kawahisa, Luke O'neill (2022). How neutrophil metabolism affects bacterial killing. Open Biology, 12(11), DOI: 10.1098/rsob.220248.
Article167 days agoThe metabolic function of pyruvate kinase M2 regulates reactive oxygen species production and microbial killing by neutrophils
Juliana E. Toller-Kawahisa, Carlos Hiroji Hiroki, Camila M. Silva, Daniele C. Nascimento, Gabriel Azevedo Públio, Timna Varela Martins, Luis Eduardo Alves Damasceno, Flávio P. Veras, Paula Ramos Viacava, Fábio Yuji Sukesada, Emily A. Day, Alessia Zotta, Tristram A. J. Ryan, Rodrigo Moreira da Silva, Thiago M. Cunha, Norberto Peporine Lopes, Fernando Q. Cunha, Luke O'neill, José C. Alves‐Filho (2023). The metabolic function of pyruvate kinase M2 regulates reactive oxygen species production and microbial killing by neutrophils. Nature Communications, 14(1), DOI: 10.1038/s41467-023-40021-6.
Article167 days agoItaconate drives mtRNA-mediated type I interferon production through inhibition of succinate dehydrogenase
Shane M. O’Carroll, Christian G. Peace, Juliana E. Toller-Kawahisa, Yukun Min, Alexander Hooftman, Sara Charki, Louise Kehoe, Maureen J. O’Sullivan, Aline Zoller, Anne F. McGettrick, Emily A. Day, Marı́a Simarro, N. Armstrong, Justin P. Annes, Luke O'neill (2024). Itaconate drives mtRNA-mediated type I interferon production through inhibition of succinate dehydrogenase. Nature Metabolism, 6(11), pp. 2060-2069, DOI: 10.1038/s42255-024-01145-1.
Article167 days ago