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Get Free AccessThis single-center retrospective study aimed to analyze the variability of macrolide resistance (MR) in 68 patients with Mycobacterium avium complex pulmonary disease. Among 25 patients treated without macrolides, 13 (52%) reverted to macrolide-susceptible (MS) profiles. Only one (2%) of 43 patients who continued macrolide treatment showed this change. We compared 30 MR isolates with recent specimens. Among them, seven shifted to MS (five attributed to clonally related strains; two resulting from reinfection or polyclonal infection).
Kiyoharu Fukushima, Yuki Matsumoto, Yuko Abe, Kazuki Hashimoto, Daisuke Motooka, Seigo Kitada, Haruko Saito, Sho Komukai, Eriko Fukui, Takayuki Niitsu, Hiroshi Nabeshima, Yasuharu Nagahama, June Yamauchi, Tadayoshi Nitta, Takuro Nii, Takanori Matsuki, Kazuyuki Tsujino, Keisuke Miki, Yasushi Shintani, Atsushi Kumanogoh, Akira Shizuo, Shota Nakamura, Hiroshi Kida (2024). Variability of macrolide-resistant profile in <i>Mycobacterium avium</i> complex pulmonary disease. Antimicrobial Agents and Chemotherapy, 68(11), DOI: 10.1128/aac.01213-24.
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Type
Article
Year
2024
Authors
23
Datasets
0
Total Files
0
Language
English
Journal
Antimicrobial Agents and Chemotherapy
DOI
10.1128/aac.01213-24
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