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Get Free AccessDendritic- cells (DCs) have received considerable attention as potential targets for the development of anticancer vaccines. DC-based anticancer vaccination relies on patient-derived DCs pulsed with a source of tumor-associated antigens (TAAs) in the context of standardized maturation-cocktails, followed by their reinfusion. Extensive evidence has confirmed that DC-based vaccines can generate TAA-specific, cytotoxic T cells. Nonetheless, clinical efficacy of DC-based vaccines remains suboptimal, reflecting the widespread immunosuppression within tumors. Thus, clinical interest is being refocused on DC-based vaccines as combinatorial partners for T cell-targeting immunotherapies. Here, we summarize the most recent preclinical/clinical development of anticancer DC vaccination and discuss future perspectives for DC-based vaccines in immuno-oncology.
Jenny Sprooten, Jolien Ceusters, An Coosemans, Patrizia Agostinis, Steven De Vleeschouwer, Laurence Zitvogel, Guido Guido Kroemer, Lorenzo Galluzzi, Abhishek D. Garg (2019). Trial watch: dendritic cell vaccination for cancer immunotherapy. , 8(11), DOI: https://doi.org/10.1080/2162402x.2019.1638212.
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Type
Article
Year
2019
Authors
9
Datasets
0
Total Files
0
Language
en
DOI
https://doi.org/10.1080/2162402x.2019.1638212
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