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Get Free AccessAbstract A unique class of IFN-producing killer dendritic cells (IKDC) resembling natural killer cells has been defined that can recognize and lyse tumor cells through a tumor necrosis factor–related apoptosis-inducing ligand–dependent mechanism. IKDC may mediate the host-dependent antitumor activity of Gleevec/STI571 and other therapeutics that can inhibit the c-kit tyrosine kinase. IKDC represent an important new component of the innate immune system responding to cancer. [Cancer Res 2007;67(3):851–3]
Evelyn Ullrich, Mathieu Bonmort, Grégoire Mignot, Nathalie Chaput, Julien Taı̈eb, Cédric Menard, Sophie Viaud, Thomas Tursz, Guido Guido Kroemer, Laurence Zitvogel (2007). Therapy-Induced Tumor Immunosurveillance Involves IFN-Producing Killer Dendritic Cells. , 67(3), DOI: https://doi.org/10.1158/0008-5472.can-06-3766.
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Type
Article
Year
2007
Authors
10
Datasets
0
Total Files
0
Language
en
DOI
https://doi.org/10.1158/0008-5472.can-06-3766
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