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Get Free AccessAlthough some evidence has been documented on EGFR/PI3K mediation of Akt activation in breast cancers, ILK and DNA-PK have not been investigated so far. The aim of this study was to analyze the expression of phosphorylated Akt (pAkt) in breast cancer, with respect to its upstream regulators. The immunostaining of pAkt (Ser473) in 70 invasive breast cancers revealed that status of CerbB2 could play a major role in Akt phosphorylation, while ILK was also involved in the stimulated level of pAkt. The results would provide an important clue for the activation of Akt and potential targeted therapy in breast cancer.
Yingkai Chi, Jing Zhao, Cui Su-ping, Ping Jiang, Huali Wang, Hong Zhang, Jing‐Zhuo Mao, Haijing Liu, Hou‐Wen Lin, Bo Zhang (2013). The level of phosphorylated Akt predominantly reflects the expressive status of CerbB2 in invasive breast cancer.. , 28(5), DOI: https://doi.org/10.14670/hh-28.655.
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Type
Article
Year
2013
Authors
10
Datasets
0
Total Files
0
Language
en
DOI
https://doi.org/10.14670/hh-28.655
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