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Get Free AccessAuf das Wasser kommt es an: Konservierte Bindungsgeometrie, enthalpiegetriebene Bindungsweise und nichtunterscheidbare Bindungsaffinitäten für fluorierte und nichtfluorierte Liganden von humaner Carbonsäureanhydrase (siehe Bild) stützen die Theorie, dass das Schlüssel-Schloss-Modell einen wichtigen Bestandteil des Bindungsvorgangs unbeachtet lässt: das Wasser, das die Bindungstasche des Proteins füllt und den Liganden umgibt.
Matthew R. Lockett, Heiko Lange, Benjamin Breiten, A. Héroux, Woody Sherman, Dmitrij Rappoport, Patricia O. Yau, Philip W. Snyder, George M M Whitesides (2013). The Binding of Benzoarylsulfonamide Ligands to Human Carbonic Anhydrase is Insensitive to Formal Fluorination of the Ligand. , 125(30), DOI: https://doi.org/10.1002/ange.201301813.
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Type
Article
Year
2013
Authors
9
Datasets
0
Total Files
0
Language
de
DOI
https://doi.org/10.1002/ange.201301813
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