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Get Free AccessNondestructive, high-efficiency, and on-demand intracellular drug/biomacromolecule delivery for therapeutic purposes remains a great challenge. Herein, a biomechanical-energy-powered triboelectric nanogenerator (TENG)-driven electroporation system is developed for intracellular drug delivery with high efficiency and minimal cell damage in vitro and in vivo. In the integrated system, a self-powered TENG as a stable voltage pulse source triggers the increase of plasma membrane potential and membrane permeability. Cooperatively, the silicon nanoneedle-array electrode minimizes cellular damage during electroporation via enhancing the localized electrical field at the nanoneedle-cell interface and also decreases plasma membrane fluidity for the enhancement of molecular influx. The integrated system achieves efficient delivery of exogenous materials (small molecules, macromolecules, and siRNA) into different types of cells, including hard-to-transfect primary cells, with delivery efficiency up to 90% and cell viability over 94%. Through simple finger friction or hand slapping of the wearable TENGs, it successfully realizes a transdermal biomolecule delivery with an over threefold depth enhancement in mice. This integrated and self-powered system for active electroporation drug delivery shows great prospect for self-tuning drug delivery and wearable medicine.
Zhirong Liu, Jinhui Nie, Bin Miao, Jiadong Li, Yuanbo Cui, Shu Wang, Xiaodi Zhang, Gengrui Zhao, Yongbo Deng, Yihui Wu, Zhou Li, Linlin Li, Zhong Lin Wang (2019). Self‐Powered Intracellular Drug Delivery by a Biomechanical Energy‐Driven Triboelectric Nanogenerator. , 31(12), DOI: https://doi.org/10.1002/adma.201807795.
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Type
Article
Year
2019
Authors
13
Datasets
0
Total Files
0
Language
en
DOI
https://doi.org/10.1002/adma.201807795
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