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Get Free AccessSummary Real‐world data have revealed that a substantial portion of patients with myelodysplastic syndromes (MDS) does not respond to epigenetic therapy with hypomethylating agents (HMAs). The cellular and molecular reasons for this resistance to the demethylating agent and biomarkers that would be able to predict the treatment refractoriness are largely unknown. In this study, we shed light on this enigma by characterizing the epigenomic profiles of patients with MDS treated with azacitidine. Our approach provides a comprehensive view of the evolving DNA methylation architecture of the disease and holds great potential for advancing our understanding of MDS treatment responses to HMAs.
Aleix Noguera‐Castells, Ignacio Campillo‐Marcos, Verónica Dávalos, Carlos A. García‐Prieto, David Valcárcel, Antonieta Molero, Laura Palomo, Norbert Gattermann, Michael Wulfert, Lorea Chaparro‐González, Françesc Solé, Marta Cabezón, María José Jiménez-Lorenzo, Blanca Xicoy, Lurdes Zamora, Alessia De Stefano, Irene Casalin, Carlo Finelli, Matilde Y. Follo, Manel Esteller (2024). <scp>DNA</scp> methylation profiling of myelodysplastic syndromes and clinical response to azacitidine: A multicentre retrospective study. , 204(5), DOI: https://doi.org/10.1111/bjh.19392.
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Type
Article
Year
2024
Authors
20
Datasets
0
Total Files
0
Language
en
DOI
https://doi.org/10.1111/bjh.19392
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