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Get Free AccessOxygen free radicals (OFR) play an important role in the pathophysiology of ischaemia/reperfusion z and drug toxicity such as that induced by doxorubicin (DX). Prostaglandins (Pgs) may protect against OFR-mediated cell injury by playing a cytoprotective role 2. Pg~s are generated through cyclooxygenase, COX-1 and COX-2. COX-1 is constitutively expressed, COX-2 is inducible. Expression and activity of cox is sensitive to oxidant stress. We examined the generation of Pgs in rat cardiomyocytes exposed to hydrogen peroxide (H20 z) and DX. DX generates the superoxide anion radical (OF-) causing its cardiotoxicity. Superoxide dismutase (SOD) and catalase (CAT) were used as free radical scavengers. An ex-vivo rat heart model was used
Simon Adderley, D J Fitzgerald, Shane O’Neill, D J Fitzgerald, N. Moran, Richard L. Smith, D J Fitzgerald, Gill Stephens, D J Fitzgerald, N. Moran, Ann M. O’Hara, Anthony P. Moran, Ann Orren, M. J. Hobart, Bruce A. Fernie, J J Connaughton, A. M. Walsh, John O’Connor, Ronan P. Murphy, Ruth Nallen, D J Fitzgerald, Claire Donoghue, Alexander S. Whitehead, Melwyn D’Mello, Mary F. McGuire, M. MacDermott, Jeffrey Glennon, William T. O’Connor, Julie Wallace, W. S. Gilmore, Jay J. Strain, J. M. Allen, D. Cantillon, A. Bradford, J. P. Ryan, T. Quinn, James Mullally, B. F. Leek, T. Quinn, J. P. Ryan, B. F. Leek, Sarah Barry, Catherine Blake, John Kiely, Paul M. Barrett, David Baxter, Suzanne McDonough, Rose Baker, T. Priori, Tara Cusack, M. Garrett, Tony Kerr, B. Caulfield, M. Garrett, Andrew N. Coogan, John O’Connor, Luke O'neill, Desiree O’Leary, John O’Connor, Sandra Davern, C. M. O’Connor, Thérèse McDonnell, D. T. Page, Neil K. O’Connor, P. Masokwane, K. M. O’Boyle, Frank Martin, Mark Rogers, Shannon L. Kelleher, A. K. Keenan (1998). Royal academy of medicine in ireland section of biomedical sciences. Irish Journal of Medical Science (1971 -), 167(3), pp. 197-205, DOI: 10.1007/bf02937936.
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Type
Article
Year
1998
Authors
70
Datasets
0
Total Files
0
Language
English
Journal
Irish Journal of Medical Science (1971 -)
DOI
10.1007/bf02937936
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