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  5. Risk of all–cause death and pancreatic events following GLP-1 RA initiation in people with obesity or type 2 diabetes: observations from a federated research network

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Article
en
2025

Risk of all–cause death and pancreatic events following GLP-1 RA initiation in people with obesity or type 2 diabetes: observations from a federated research network

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en
2025
Vol 24 (1)
Vol. 24
DOI: 10.1186/s12933-025-02986-0

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Professor Gregory Lip
Professor Gregory Lip

University of Liverpool

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Enrico Tartaglia
Tommaso Bucci
Michele Rossi
+6 more

Abstract

GLP-1 RA use was associated with substantially reduced all-cause death but a small increased risk of acute pancreatitis, particularly during early treatment. The survival benefit was more pronounced in younger people and those with cardiometabolic comorbidities, highlighting the need for a careful risk-benefit evaluation when prescribing GLP-1 RAs in high-risk individuals.

How to cite this publication

Enrico Tartaglia, Tommaso Bucci, Michele Rossi, Andrea Galeazzo Rigutini, Amir Askarinejad, Uazman Alam, Katarzyna Nabrdalik, Giuseppe Boriani, Professor Gregory Lip (2025). Risk of all–cause death and pancreatic events following GLP-1 RA initiation in people with obesity or type 2 diabetes: observations from a federated research network. , 24(1), DOI: https://doi.org/10.1186/s12933-025-02986-0.

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Publication Details

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Article

Year

2025

Authors

9

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0

Language

en

DOI

https://doi.org/10.1186/s12933-025-02986-0

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