Reply to Pandey et al.: Understanding the efficacy of a potential antiretroviral drug candidate in humanized mouse model of HIV infection

We appreciate Pandey et al.’s (1) interest in further understanding our published work (2). Our responses are given below the excerpts from the Letter.Our first and foremost concern is the data presented in their figure 6C. We fail to understand why there was a fall in the plasma viral loads after day 19 in the control group (i.e., the group not given any intervention). Furthermore, not only was the fall in the plasma viral load significant (to below the limit of detection; <150 copies per milliliter) but also it was more rapid (showing a steeper decline) compared with the treated groups by day 32. If the viral loads are decreasing so rapidly and significantly in the noninterventional (control group), can we draw conclusions about the efficacy of … [↵][1]1To whom correspondence should be addressed. Email: william.jorgensen{at}yale.edu. [1]: #xref-corresp-1-1