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Get Free AccessSignificance Idiopathic inflammatory bowel disease (IBD) is associated with the gut microbiota and immune system of the host; however, the precise pathogenesis of IBD is poorly defined. We show that specific deletion of the endoribonuclease Regnase-1 in intestinal epithelial cells relieves the symptoms of experimental colitis during acute inflammation. Regnase-1 deficiency potentiates mTOR signaling and purine metabolism in the colon epithelium. These data provide insight into the role of epithelial Regnase-1 in IBD.
Yasuharu Nagahama, Mayuko Shimoda, Guoliang Mao, Shailendra Kumar Singh, Yuuki Kozakai, Xin Sun, Daisuke Motooka, Shota Nakamura, Hiroki Tanaka, Takashi Satoh, Kazuhiko Maeda, Akira Shizuo (2018). Regnase-1 controls colon epithelial regeneration via regulation of mTOR and purine metabolism. Proceedings of the National Academy of Sciences, 115(43), pp. 11036-11041, DOI: 10.1073/pnas.1809575115.
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Type
Article
Year
2018
Authors
12
Datasets
0
Total Files
0
Language
English
Journal
Proceedings of the National Academy of Sciences
DOI
10.1073/pnas.1809575115
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