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Get Free AccessHepatocellular carcinoma (HCC) has emerged as a major cause of cancer deaths globally. The landscape of systemic therapy has recently changed, with six additional systemic agents either approved or awaiting approval for advanced stage HCC. While these agents have the potential to improve outcomes, a survival increase of 2-5 months remains poor and falls short of what has been achieved in many other solid tumor types. The roles of genomics, underlying cirrhosis, and optimal use of treatment strategies that include radiation, liver transplantation, and surgery remain unanswered. Here, we discuss new treatment opportunities, controversies, and future directions in managing HCC.
Mark Yarchoan, Parul Agarwal, Augusto Villanueva, Shuyun Rao, Laura A. Dawson, Thomas B. Karasic, Josep M. Llovet, Richard S. Finn, John D. Groopman, Hashem B. El–Serag, Satdarshan P. Monga, Xin Wei Wang, Michael Karin, Robert E. Schwartz, Kenneth K. Tanabe, Lewis R. Roberts, Preethi H. Gunaratne, Allan Tsung, Kimberly Brown, Theodore S. Lawrence, Riad Salem, Amit G. Singal, Amy K. Kim, Atoosa Rabiee, Linda Resar, Jeffrey Meyer, Yujin Hoshida, Aiwu Ruth He, Kalpana Ghoshal, Patrick Ryan, Elizabeth M. Jaffee, Chandan Guha, Lopa Mishra, C. Norman Coleman, Mansoor M. Ahmed (2019). Recent Developments and Therapeutic Strategies against Hepatocellular Carcinoma. Cancer Research, 79(17), pp. 4326-4330, DOI: 10.1158/0008-5472.can-19-0803.
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Type
Article
Year
2019
Authors
35
Datasets
0
Total Files
0
Language
English
Journal
Cancer Research
DOI
10.1158/0008-5472.can-19-0803
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