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Get Free AccessBackground. Cytoadherence and sequestration of erythrocytes containing mature stages of Plasmodium falciparum are central to the pathogenesis of severe malaria. The oral anthelminthic drug levamisole inhibits cytoadherence in vitro and reduces sequestration of late-stage parasites in uncomplicated falciparum malaria treated with quinine.
Richard J. Maude, Kamolrat Silamut, Katherine Plewes, Prakaykaew Charunwatthana, May Ho, M. Abul Faiz, Ridwanur Rahman, Md Amir Hossain, Mahtab Uddin Hassan, Emran Bin Yunus, Gofranul Hoque, Faridul Islam, Aniruddha Ghose, Josh Hanson, Joël Schlatter, Rachel Lacey, Alison Eastaugh, Joel Tärning, Sue J. Lee, Sir Nicholas White, Kesinee Chotivanich, Nicholas Day, Arjen M. Dondorp (2013). Randomized Controlled Trial of Levamisole Hydrochloride as Adjunctive Therapy in Severe Falciparum Malaria With High Parasitemia. The Journal of Infectious Diseases, 209(1), pp. 120-129, DOI: 10.1093/infdis/jit410.
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Type
Article
Year
2013
Authors
23
Datasets
0
Total Files
0
Language
English
Journal
The Journal of Infectious Diseases
DOI
10.1093/infdis/jit410
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