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Get Free AccessArtemether (AM) plus azithromycin (AZ) rectal co-formulations were studied to provide pre-referral treatment for children with severe febrile illnesses in malaria-endemic areas. The target profile required that such product should be cheap, easy to administer by non-medically qualified persons, rapidly effective against both malaria and bacterial infections. Analytical and pharmacotechnical development, followed by in vitro and in vivo evaluation, were conducted for various AMAZ coformulations. Of the formulations tested, stability was highest for dry solid forms and bioavailability for hard gelatin capsules; AM release from AMAZ rectodispersible tablet was suboptimal due to a modification of its micro-crystalline structure.
Alexandra Gaubert, Tina Kauss, Mathieu Marchivie, Boubakar B. Ba, Martine Lembege, Fawaz Fawaz, Jean‐Michel Boiron, Xavier Lafarge, Niklas Lindegårdh, J Fabre, Sir Nicholas White, Piero Olliaro, Pascal Millet, Karen Gaudin (2014). Preliminary pharmaceutical development of antimalarial–antibiotic cotherapy as a pre-referral paediatric treatment of fever in malaria endemic areas. International Journal of Pharmaceutics, 468(1-2), pp. 55-63, DOI: 10.1016/j.ijpharm.2014.04.023.
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Type
Article
Year
2014
Authors
14
Datasets
0
Total Files
0
Language
English
Journal
International Journal of Pharmaceutics
DOI
10.1016/j.ijpharm.2014.04.023
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