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Get Free AccessUnlike most of the other Cas proteins, Cas4 family members are as often encoded by stand-alone genes as they are incorporated in CRISPR-Cas systems. In addition, cas4 genes were repeatedly recruited by MGE, perhaps, for anti-defense functions. Experimental characterization of the solo and MGE-encoded Cas4 nucleases is expected to reveal currently uncharacterized defense and anti-defense systems and their interactions with CRISPR-Cas systems.
Sanjarbek Hudaiberdiev, Sergey Shmakov, Yuri I. Wolf, Michael P. Terns, Kira S. Makarova, Eugene V Koonin (2017). Phylogenomics of Cas4 family nucleases. , 17(1), DOI: https://doi.org/10.1186/s12862-017-1081-1.
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Type
Article
Year
2017
Authors
6
Datasets
0
Total Files
0
Language
en
DOI
https://doi.org/10.1186/s12862-017-1081-1
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