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Get Free AccessPatients with metastatic castration-resistant prostate cancer (mCRPC) and BRCA alterations have poor outcomes. MAGNITUDE found patients with homologous recombination repair gene alterations (HRR+), particularly BRCA1/2, benefit from first-line therapy with niraparib plus abiraterone acetate and prednisone (AAP). Here we report longer follow-up from the second prespecified interim analysis (IA2).
K.N. Chi, Shahneen Sandhu, Matthew R. Smith, Gerhardt Attard, Marniza Saad, David Olmos, Elena Castro, Guilhem Roubaud, Andrea Juliana Gomes, Eric J. Small, Dana E. Rathkopf, Howard Gurney, Wonho Jung, Gary Mason, Shiva Dibaj, Daphne Wu, B. Diorio, Karen A. Urtishak, A. del Corral, Peter Francis, W. Kim, Eleni Efstathiou (2023). Niraparib plus abiraterone acetate with prednisone in patients with metastatic castration-resistant prostate cancer and homologous recombination repair gene alterations: second interim analysis of the randomized phase III MAGNITUDE trial. , 34(9), DOI: https://doi.org/10.1016/j.annonc.2023.06.009.
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Type
Article
Year
2023
Authors
22
Datasets
0
Total Files
0
Language
en
DOI
https://doi.org/10.1016/j.annonc.2023.06.009
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